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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Julin Luo, Min Tan, Zhen Dai, Manyun Xie, Minzhu Lin, Jiao Hua, Huiying Ma, Qing Zhao, Jinshun Liu, Aiming |
| Description | Country affiliation: China Author Affiliation: Yang J ( Ningbo College of Health Sciences, Ningbo 315100, China.); Luo M ( Medical School of Ningbo University, Ningbo 315211, China.); Tan Z ( Medical School of Ningbo University, Ningbo 315211, China.); Dai M ( Medical School of Ningbo University, Ningbo 315211, China.); Xie M ( Medical School of Ningbo University, Ningbo 315211, China.); Lin J ( Medical School of Ningbo University, Ningbo 315211, China.); Hua H ( Medical School of Ningbo University, Ningbo 315211, China.); Ma Q ( Medical School of Ningbo University, Ningbo 315211, China.); Zhao J ( Medical School of Ningbo University, Ningbo 315211, China.); Liu A ( Medical School of Ningbo University, Ningbo 315211, China. Electronic address: liuaiming@nbu.edu.cn.) |
| Abstract | TiO nano-particle (TiO NP) is widely used in industrial, household necessities, as well as medicinal products. However, the effect of TiO NP on liver metabolic function has not been reported. In this study, after mice were orally administered TiO NP (21nm) for 14days, the serum and liver tissues were assayed by biochemical analysis, real time quantitative polymerase chain reaction, western blot and transmission electron microscopy. The serum bilirubin was increased in a dose dependent manner. Deposition of TiO NP in hepatocytes and the abnormality of microstructures was observed. Expression of metabolic genes involved in the endogenous and exogenous metabolism was modified, supporting the toxic phenotype. Collectively, oral administration of TiO NP (21nm) led to deposition of particles in hepatocytes, mitochondrial edema, and the disturbance of liver metabolism function. These data suggested oral administration disrupts liver metabolic functions, which was more sensitive than regular approaches to detect material hepatotoxicity. This study provided useful information for risk analysis and regulation of TiO NPs by administration agencies. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Volume Number | 49 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Liver Drug Effects Metal Nanoparticles Toxicity Titanium Administration, Oral Alanine Transaminase Blood Animals Apoptosis Regulatory Proteins Genetics Aspartate Aminotransferases Cytochrome P-450 Enzyme System Metabolism Cytokines Gene Expression Regulation Glucuronosyltransferase Ultrastructure Male Mice, Inbred C57bl Microscopy, Electron, Transmission Rna, Messenger Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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