NDLI: Tigecycline in vitro activity against commonly encountered multidrug-resistant gram-negative pathogens in a Middle Eastern country.

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Tigecycline in vitro activity against commonly encountered multidrug-resistant gram-negative pathogens in a Middle Eastern country.

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Tigecycline in vitro activity against commonly encountered multidrug-resistant gram-negative pathogens in a Middle Eastern country.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Araj, George F. Ibrahim, Georges Y.
Spatial Coverage	Lebanon
Description	Country affiliation: Lebanon Author Affiliation: Araj GF ( Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box 116-3044, Beirut 11077-2020, Lebanon. garaj@aub.edu.lb)
Abstract	The lack of data from the Middle East warranted studying tigecycline in vitro activity in Lebanon against consecutive multidrug-resistant (MDR) bacteria, including extended-spectrum beta-lactamases producing clinical isolates of Escherichia coli (n = 150), Klebsiella pneumoniae (n = 100), and Acinetobacter spp. (n = 64) using the standard disk diffusion method. Tigecycline-resistant and intermediate findings were as follows: E. coli, 0% and 0%; K. pneumoniae, 3% and 16%; and Acinetobacter spp., 0% and 2%. These values were substantially lower than those determined for amikacin, gentamicin, tobramycin, ciprofloxacin, piperacillin/tazobactam, amoxicillin/clavulanic acid, and trimethoprim/sulfamethoxazole. This study demonstrates the excellent activity of tigecycline against the increasingly encountered MDR bacteria in Lebanon. The introduction of this effective and viable drug for the initial or recommended treatment of serious infections caused by such highly resistant pathogens is an asset for patients in this country and elsewhere.
File Format	HTM / HTML
ISSN	07328893
Issue Number	4
Volume Number	62
e-ISSN	18790070
Journal	Diagnostic Microbiology and Infectious Disease
Language	English
Publisher	Elsevier
Publisher Date	2008-12-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Microbiology Discipline Communicable Diseases Anti-bacterial Agents Pharmacology Drug Resistance, Multiple, Bacterial Gram-negative Bacteria Drug Effects Minocycline Analogs & Derivatives Adolescent Adult Child Child, Preschool Gram-negative Bacterial Infections Epidemiology Microbiology Humans Infant Lebanon Middle Aged Journal Article
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology (medical)

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Tigecycline in vitro activity against commonly encountered multidrug-resistant gram-negative pathogens in a Middle Eastern country.

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