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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cobo, Javier Lora-Tamayo, Jaime Euba, Gorane Jover-Sáenz, Alfredo Palomino, Julián Del Toro, Ma Dolores Rodríguez-Pardo, Dolors Riera, Melchor Ariza, Javier |
| Organization | Red Espanola para la Investigacion en Patologia Infecciosa (REIPI) |
| Description | Country affiliation: Spain Author Affiliation: Cobo J ( Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain. jcobo.hrc@salud.madrid.org) |
| Abstract | Linezolid may be an interesting alternative for prosthetic joint infection (PJI) due to its bioavailability and its antimicrobial spectrum. However, experience in this setting is scarce. The aim of the study was to assess linezolid's clinical and microbiological efficacy, and also its tolerance. This was a prospective, multicenter, open-label, non-comparative study of 25 patients with late-chronic PJI caused by Gram-positive bacteria managed with a two-step exchange procedure plus 6 weeks of linezolid. Twenty-two (88%) patients tolerated linezolid without major adverse effects, although a global decrease in the platelet count was observed. Three patients were withdrawn because of major toxicity, which reversed after linezolid stoppage. Among patients who completed treatment, 19 (86%) demonstrated clinical and microbiological cure. Two patients presented with clinical and microbiological failure, and one showed clinical cure and microbiological failure. In conclusion, linezolid showed good results in chronic PJI managed with a two-step exchange procedure. Tolerance seems acceptable, though close surveillance is required. |
| File Format | HTM / HTML |
| ISSN | 07328893 |
| Issue Number | 1 |
| Volume Number | 76 |
| e-ISSN | 18790070 |
| Journal | Diagnostic Microbiology and Infectious Disease |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Discipline Communicable Diseases Acetamides Therapeutic Use Anti-bacterial Agents Arthritis Microbiology Gram-positive Bacteria Isolation & Purification Oxazolidinones Prosthesis-related Infections Drug Therapy Pharmacokinetics Aged Aged, 80 And Over Surgery Female Drug Effects Humans Linezolid Male Middle Aged Prospective Studies Treatment Outcome Clinical Trial Journal Article Multicenter Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Microbiology (medical) |
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