NDLI: Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya.

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Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hampton, Lee M. Bigogo, Godfrey Jagero, Geofrey da Gloria Carvalho, Maria Pimenta, Fabiana Junghae, Muthoni Breiman, Robert F. Whitney, Cynthia G. Feikin, Daniel R. Conklin, Laura M.
Description	Author Affiliation: Hampton LM ( Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA); Bigogo G ( Kenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.); Jagero G ( Kenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.); da Gloria Carvalho M ( Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA.); Pimenta F ( Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA.); Junghae M ( Kenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.); Breiman RF ( Kenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.); Whitney CG ( Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA.); Feikin DR ( Kenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya.); Conklin LM ( Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA.)
Abstract	When used in an area of rural western Kenya, the BinaxNOW® urine antigen test had a sensitivity of 67% (95% Confidence Interval [CI]: 43-85%) among 21 adults ≥15 years old with acute respiratory illnesses and pneumococcal bacteremia and a specificity of 98% (95% CI: 96-99%) among 660 adults ≥15 years old without fever or cough. The specificity of the test was not significantly affected by pneumococcal colonization, regardless of patients' HIV status, age, or sex. Use of the pneumococcal urine antigen test in clinical assessments of adults in Africa with acute respiratory illness is a viable option regardless of whether a patient is colonized by pneumococci, even among HIV-infected adults, although the moderate sensitivity of the urine antigen test indicates that the test is probably best used clinically as part of a panel with other tests that can detect pneumococci.
File Format	HTM / HTML
ISSN	07328893
Issue Number	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume Number	85
e-ISSN	18790070
Language	English
Publisher	Elsevier
Publisher Date	2016-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Microbiology Discipline Communicable Diseases
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology (medical)

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RAPID DIAGNOSIS OF PNEUMOCOCCAL PNEUMONIA AMONG HIV-INFECTED ADULTS WITH URINE ANTIGEN DETECTION

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