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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wolff, Tanya |
| Abstract | INTRODUCTIONThe Drosophila eye has been used to study a broad range of topics, such as signal transduction, cell-fate specification, morphogenesis, and cell death. The eye has a relatively simple cellular architecture: the ommatidia (unit eyes of the compound eye) are composed of a small number of cells, and these cells can be readily identified on the basis of their shape and location within an ommatidium. Also, because the eye is a monolayer epithelium, all cells can be viewed in whole-mount preparations in both the larval imaginal disc and the pupal eye. Mosaic analysis is a powerful genetic tool that is routinely used in the eye to determine a given cell's requirement for a gene of interest. Such analyses are possible because cell fates are determined on the basis of positional cues. Furthermore, pattern formation proceeds as a wave of morphogenesis sweeps across the eye disc. Thus, all early patterning events are laid out in a single imaginal disc preparation. A final attractive feature of the eye is that it is dispensable for viability and development, and therefore a number of tools have been developed for its manipulation. |
| File Format | HTM / HTML |
| ISSN | 19403402 |
| Journal | Cold Spring Harbor Protocols |
| Volume Number | 2007 |
| e-ISSN | 15596095 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2007-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Laboratory Techniques |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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