NDLI: Polylysine copolymers for gene delivery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Sung Wan
Abstract	Polylysine and its copolymers have been extensively used as nonviral polymeric gene carriers. Although polylysine on its own is toxic to cells, when polyethylene glycol is covalently linked to polylysine, toxicity is reduced and DNA transfection efficiency is increased. A degradable polylysine analog, polyaminobutyl glycolic acid, has been synthesized. Stearyl polylysine shows strong hydrophobic interactions with low-density lipoprotein and these components can be combined with DNA to form a 'terplex' system that allows delivery of DNA to targeted cells and significant levels of transfection both in vitro and in vivo.
File Format	HTM / HTML
ISSN	19403402
Issue Number	4
Volume Number	2012
e-ISSN	15596095
Journal	Cold Spring Harbor Protocols
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2012-04-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Clinical Laboratory Techniques Dna Metabolism Gene Transfer Techniques Polyethylene Glycols Chemistry Polylysine Animals Cell Line Humans Hydrophobic And Hydrophilic Interactions Journal Article
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology

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Polylysine copolymers for gene delivery.