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Analyses of tumor-suppressor genes in germline mouse models of cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Jingqiang Abate-Shen, Cory
Description	Author Affiliation: Wang J ( Departments of Urology and Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032.); Abate-Shen C ( Departments of Urology and Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032.)
Abstract	Tumor-suppressor genes are critical regulators of growth and functioning of cells, whose loss of function contributes to tumorigenesis. Accordingly, analyses of the consequences of their loss of function in genetically engineered mouse models have provided important insights into mechanisms of human cancer, as well as resources for preclinical analyses and biomarker discovery. Nowadays, most investigations of genetically engineered mouse models of tumor-suppressor function use conditional or inducible alleles, which enable analyses in specific cancer (tissue) types and overcome the consequences of embryonic lethality of germline loss of function of essential tumor-suppressor genes. However, historically, analyses of genetically engineered mouse models based on germline loss of function of tumor-suppressor genes were very important as these early studies established the principle that loss of function could be studied in mouse cancer models and also enabled analyses of these essential genes in an organismal context. Although the cancer phenotypes of these early germline models did not always recapitulate the expected phenotypes in human cancer, these models provided the essential foundation for the more sophisticated conditional and inducible models that are currently in use. Here, we describe these 'first-generation' germline models of loss of function models, focusing on the important lessons learned from their analyses, which helped in the design and analyses of 'next-generation' genetically engineered mouse models.
File Format	HTM / HTML
ISSN	19403402
e-ISSN	15596095
DOI	10.1101/pdb.top069773
Journal	Cold Spring Harbor Protocols
Issue Number	8
Volume Number	2014
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2014-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Clinical Laboratory Techniques Genes, Tumor Suppressor Neoplasms Pathology Animals Disease Models, Animal Gene Expression Regulation Germ-line Mutation History, 20th Century History, 21st Century Mice Historical Article Introductory Journal Article
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology

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