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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zender, Lars Hemann, Michael |
| Description | Author Affiliation: Zender L ( Division of Molecular Oncology of Solid Tumors, Department of Internal Medicine I, University Hospital, 72076 Tübingen, Germany); Hemann M ( Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.) |
| Abstract | Hepatic progenitor cells isolated from fetal liver can be transplanted into recipient mice to reconstitute an organ system. Retroviral infection can be used to introduce putative oncogenes or short-hairpin RNAs (shRNAs) targeting putative tumor suppressors into the cells; reconstituted mice then develop livers that are chimeric for cells bearing a specific alteration. This approach has the advantage of examining tumorigenesis on a largely wild-type background (if only a subset of cells are infected), a situation that more accurately parallels the human situation. Additionally, tumor development occurs within the appropriate native microenvironment. Here, we describe the isolation of hepatic progenitor cells, as well as the reconstitution and tumor monitoring of recipient mice. |
| File Format | HTM / HTML |
| ISSN | 19403402 |
| Issue Number | 7 |
| Volume Number | 2015 |
| e-ISSN | 15596095 |
| Journal | Cold Spring Harbor Protocols |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2015-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Laboratory Techniques Hematopoietic Stem Cell Transplantation Methods Hematopoietic Stem Cells Virology Liver Physiology Organisms, Genetically Modified Retroviridae Genetics Stem Cells Transduction, Genetic Animals Disease Models, Animal Hematologic Neoplasms Pathology Therapy Mice Growth & Development Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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