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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kabeer, Farhia Beverly, Levi J. Darrasse-Jèze, Guillaume Podsypanina, Katrina |
| Description | Author Affiliation: Kabeer F ( Institut de Recherches Cliniques de Montréal, Montréal, Quebec H2W 1R7, Canada); Beverly LJ ( Department of Medicine, University of Louisville, Louisville, Kentucky 40202); Darrasse-Jèze G ( Université Pierre et Marie Curie, Université Paris 06, Unité Mixte de Recherche 7211); Podsypanina K ( Institut de Recherches Cliniques de Montréal, Montréal, Quebec H2W 1R7, Canada) |
| Abstract | Metastasis is often modeled by xenotransplantation of cell lines in immunodeficient mice. A wealth of information about tumor cell behavior in the new environment is obtained from these efforts. Yet by design, this approach is 'tumor-centric,' as it focuses on cell-autonomous determinants of human tumor dissemination in mouse tissues, in effect using the animal body as a sophisticated 'Petri dish' providing nutrients and support for tumor growth. Transgenic or gene knockout mouse models of cancer allow the study of tumor spread as a systemic disease and offer a complimentary approach for studying the natural history of cancer. This introduction is aimed at describing the overall methodological approach to studying metastasis in genetically modified mice, with a particular focus on using animals with regulated expression of potent human oncogenes in the breast. |
| File Format | HTM / HTML |
| ISSN | 19403402 |
| Issue Number | 2 |
| Journal | Cold Spring Harbor Protocols |
| Volume Number | 2016 |
| e-ISSN | 15596095 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2016-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Laboratory Techniques Mice, Transgenic Neoplasm Metastasis Pathology Animals Mice Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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