NDLI: Prions.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kryndushkin, Dmitry Edskes, Herman K. Shewmaker, Frank P. Wickner, Reed B.
Description	Author Affiliation: Kryndushkin D ( Department of Pharmacology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814.); Edskes HK ( Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0830.); Shewmaker FP ( Department of Pharmacology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814.); Wickner RB ( Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0830 wickner@helix.nih.gov.)
Abstract	Infectious proteins (prions) are usually self-templating filamentous protein polymers (amyloids). Yeast prions are genes composed of protein and, like the multiple alleles of DNA-based genes, can have an array of 'variants,' each a distinct self-propagating amyloid conformation. Like the lethal mammalian prions and amyloid diseases, yeast prions may be lethal, or only mildly detrimental, and show an array of phenotypes depending on the protein involved and the prion variant. Yeast prions are models for both rare mammalian prion diseases and for several very common amyloidoses such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease. Here, we describe their detection and characterization using genetic, cell biological, biochemical, and physical methods.
File Format	HTM / HTML
ISSN	19403402
Issue Number	2
Journal	Cold Spring Harbor Protocols
Volume Number	2017
e-ISSN	15596095
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2017-02-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Clinical Laboratory Techniques
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology

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