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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Yu-Wei Chen, Yi-Chou Wu, Chih-Jen Chen, Han-Hsiang |
| Description | Country affiliation: Taiwan Author Affiliation: Chen YW ( Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.) |
| Abstract | BACKGROUND: Pioglitazone is a peroxisome proliferator-activated receptor-gamma agonist that decreases insulin resistance in type 2 diabetes mellitus. However, it has been associated with fluid retention, peripheral edema, and congestive heart failure, which has become of particular concern. There are no reports in the literature of severe pleural effusions in a patient with normal cardiac function. CASE SUMMARY: A 54-year-old Asian woman weighing 77 kg developed massive bilateral pleural effusion after receiving pioglitazone (30 mg QD) in combination with glimepiride 2 mg BID and metformin 500 mg TID. Despite treatment with furosemide (20 mg intravenously at 12-hour intervals for 4 days) and a decrease in weight from 77 to 72 kg, the effusion persisted. However, it began to decrease after pioglitazone was discontinued, and it had resolved completely when the patient was evaluated on follow-up 1 month later in the outpatient department. CONCLUSIONS: This article reports a case of massive bilateral pleural effusion found in a patient with normal cardiac function who was receiving pioglitazone. After the drug was discontinued, the effusion resolved completely, indicating a probable adverse drug reaction. |
| File Format | HTM / HTML |
| ISSN | 01492918 |
| Issue Number | 8 |
| Volume Number | 30 |
| e-ISSN | 1879114X |
| Journal | Clinical Therapeutics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-08-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Diabetes Mellitus, Type 2 Drug Therapy Hypoglycemic Agents Adverse Effects Pleural Effusion Chemically Induced Thiazolidinediones Diuretics Therapeutic Use Female Furosemide Humans Middle Aged Severity Of Illness Index Case Reports Journal Article |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Pharmacology Pharmacology (medical) |
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