NDLI: Impact of long-term statin treatment on coronary plaque composition at angiographically severe lesions: a nonrandomized study of the history of long-term statin treatment before coronary angioplasty.

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Impact of long-term statin treatment on coronary plaque composition at angiographically severe lesions: a nonrandomized study of the history of long-term statin treatment before coronary angioplasty.

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Impact of long-term statin treatment on coronary plaque composition at angiographically severe lesions: a nonrandomized study of the history of long-term statin treatment before coronary angioplasty.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miyagi, Motohiro Ishii, Hideki Murakami, Ryuichiro Isobe, Satoshi Hayashi, Mutsuharu Amano, Tetsuya Arai, Kosuke Ohashi, Taiki Uetani, Tadayuki Matsubara, Tatsuaki Murohara, Toyoaki
Spatial Coverage	Japan
Description	Country affiliation: Japan Author Affiliation: Miyagi M ( Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.)
Abstract	BACKGROUND: Studies have found an association between treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ('statins') and reductions in procedure-related complications in percutaneous coronary intervention (PCI). OBJECTIVE: This study investigated the effects of long-term statin treatment before elective PCI on coronary plaque composition at the angiographically severe target stenotic lesions. METHODS: This nonrandomized, observational study was conducted at Nagoya University Hospital, Nagoya, Japan. Data were collected from the electronic medical records of patients with stable angina pectoris who underwent PCI guided by intravascular ultrasound (IVUS). Patients were stratified into 2 groups: those who received long-term statin treatment for > or =6 months before PCI (statin group) and those who did not (nonstatin group). The tissue characteristics of the coronary plaque at each target stenotic site were analyzed using 3-dimensional integrated backscatter IVUS immediately before PCI. RESULTS: Data from 100 patients were included (91 men, 9 women; mean [SD] age, 67 [10] years; statin group, 44 patients; nonstatin group, 56). The clinical characteristics of the 2 groups were not significantly different, with the exception of the prevalence of hyperlipidemia (statin vs nonstatin, 100% vs 51.8%; P < 0.001). There were no significant between-group differences in serum lipid profiles. The statin group had a significantly greater mean (SD) percentage decrease in lipid volume (28.7% [10.0%] vs 34.7% [9.8%]; P = 0.003) and a significantly greater increase in fibrous volume (66.5% [8.5%] vs 60.9% [8.6%]; P = 0.001) compared with the nonstatin group. CONCLUSION: This study found a significant difference in lipid and fibrous volumes in angiographically severe coronary stenotic lesions in these patients with stable angina who received long-term statin treatment before PCI versus those who did not.
File Format	HTM / HTML
ISSN	01492918
Issue Number	1
Volume Number	31
e-ISSN	1879114X
Journal	Clinical Therapeutics
Language	English
Publisher	Elsevier
Publisher Date	2009-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Angina Pectoris Therapy Angioplasty, Balloon, Coronary Methods Coronary Stenosis Drug Therapy Hydroxymethylglutaryl-coa Reductase Inhibitors Administration & Dosage Aged Adverse Effects Coronary Angiography Pathology Female Hospitals, University Humans Japan Epidemiology Male Middle Aged Postoperative Complications Prevention & Control Time Factors Controlled Clinical Trial Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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Impact of long-term statin treatment on coronary plaque composition at angiographically severe lesions: a nonrandomized study of the history of long-term statin treatment before coronary angioplasty.

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