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Psychometric performance of the incontinence quality-of-life questionnaire among patients with overactive bladder and urinary incontinence.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Patrick, Donald L. Khalaf, Kristin M. Dmochowski, Roger Kowalski, Jonathan W. Globe, Denise R.
Description	Country affiliation: United States Author Affiliation: Patrick DL ( University of Washington School of Public Health, Seattle, Washington, USA. donald@u.washington.edu)
Abstract	BACKGROUND: The Incontinence Quality-of-Life Instrument (I-QOL) is a condition-specific questionnaire that assesses the health-related QOL impact of urinary incontinence, but it has not been validated in patients with overactive bladder (OAB) who have been inadequately managed by anticholinergic therapy. OBJECTIVE: This study assessed the reliability and validity of the I-QOL among patients with OAB with urinary incontinence. METHODS: I-QOL scores were analyzed from a Phase II study that compared the efficacy and tolerability of onabotulinumtoxinA and placebo. Conceptual framework was confirmed via confirmatory factor analysis. Reliability was assessed using Cronbach's alpha and intraclass correlation coefficients (ICCs). Validity was tested by comparing I-QOL scores to tertiles of urinary symptom severity. Effect size statistics estimated the ability of the I-QOL to detect change. Responder analysis with cumulative distribution function was plotted to show differentiation between treatment groups with respect to I-QOL scores. RESULTS: Comparative fit indices ranged from 0.87 to 0.99 on the confirmatory factor analysis. I-QOL scores showed high internal consistency (0.86 ≤ Cronbach's ≤ 0.93), good test-retest reliability (0.68 ≤ ICC ≤ 0.84), and good differentiation between tertiles of increasing urinary symptom severity (all, P ≤ 0.002). Significant differences in I-QOL change scores were noted between responders and nonresponders across all responder definitions (all, P < 0.001) and corresponded with large effect sizes among responders to treatment (1.34 ≤ effect size ≤ 2.82). CONCLUSION: This study demonstrated that OAB with urinary incontinence affects health-related QOL and that the I-QOL reliably and validly measures these impacts.
File Format	HTM / HTML
ISSN	01492918
Issue Number	6
Volume Number	35
e-ISSN	1879114X
Journal	Clinical Therapeutics
Language	English
Publisher	Elsevier
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Quality Of Life Questionnaires Urinary Bladder, Overactive Psychology Urinary Incontinence Adolescent Adult Aged Aged, 80 And Over Botulinum Toxins, Type A Administration & Dosage Female Humans Male Middle Aged Psychometrics Reproducibility Of Results Diagnosis Drug Therapy Physiopathology Young Adult Clinical Trial, Phase Ii Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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