NDLI: The role of adiponectin as a compensatory mediator for the primary secretory defect in latent autoimmune diabetes in adults.

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The role of adiponectin as a compensatory mediator for the primary secretory defect in latent autoimmune diabetes in adults.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hatziagelaki, Erifili Lambadiari, Vaia Tsiavou, Anastasia Gogas, Helen Bretzel, Reinhard G. Dimitriadis, George
Description	Country affiliation: Greece Author Affiliation: Hatziagelaki E ( 2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University, Attikon, University General Hospital, Athens, Greece. erihat@otenet.gr)
Abstract	BACKGROUND: Increased adiposity in patients with newly diagnosed type 2 diabetes mellitus (DM), as well as in patients who do not have DM, affects the regulation of insulin sensitivity and the metabolic effects of adiponectin. OBJECTIVE: The goal of this study was to investigate the relationship between plasma adiponectin levels and obesity in patients developing DM mainly due to an early decline in ß-cell function. METHODS: We studied 29 patients with latent autoimmune diabetes in adults (LADA), 38 patients with type 1 DM, and 55 healthy volunteers. RESULTS: Plasma adiponectin levels, adjusted for body mass index (BMI), were higher in patients with type 1 DM than in controls (P < 0.001) and similar to those in patients with LADA (P = 0.464). Plasma adiponectin levels were higher in LADA patients compared with controls (P < 0.001). In LADA patients, plasma adiponectin levels, adjusted for BMI, correlated significantly with insulin resistance (ß coefficient, -6.453 [2.772]; P = 0.028). Interestingly, this relationship in LADA patients was significant in more overweight patients (ß coefficient, -7.142 [3.249]; P = 0.048) but not in leaner patients (P = 0.571), a finding that was not confirmed through the results in the controls (P = 0.520 and P = 0.992, respectively). CONCLUSIONS: In patients with LADA, increases in plasma adiponectin levels, after adjustment for BMI, could act as a mediator for improvement in insulin sensitivity and thus compensate for the primary secretory defect. This effect seems more profound in more overweight subjects than in leaner subjects.
File Format	HTM / HTML
ISSN	01492918
Issue Number	7
Volume Number	35
e-ISSN	1879114X
Journal	Clinical Therapeutics
Language	English
Publisher	Elsevier
Publisher Date	2013-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Adiponectin Blood Diabetes Mellitus, Type 1 Insulin Resistance Obesity Metabolism Adult Body Mass Index Immunology Female Humans Insulin Interleukin-6 Male Physiopathology Overweight Regression Analysis Tumor Necrosis Factor-alpha Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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