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Detecting infection in neonates: promises and challenges of a salivary approach.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Iyengar, Anjali Maron, Jill L.
Description	Author Affiliation: Iyengar A ( Tufts Medical Center, Boston, Massachusetts. Electronic address: aiyengar@tuftsmedicalcenter.org.); Maron JL ( Mother Infant Research Institute at Tufts Medical Center, Boston, Massachusetts.)
Abstract	Premature newborns present unique challenges for the caregiver. Their clinical fragility and immature immune system places them at increased risk for bacterial and viral infections. Current clinical standard of care mandates invasive phlebotomy to assess an infant for an infection. However, serial blood draws can lead to blood transfusions and the infliction of noxious stimuli to this vulnerable population. Salivary screening for common neonatal morbidities, such as infections, could vastly improve the care for these infants and positively affect their long-term clinical outcomes. Recent technological advancements have improved our ability to detect thousands of proteins and/or microbes from a single salivary sample, making noninvasive assessment in neonates a possibility. This article reviews the clinical applications and challenges associated with integrating salivary analysis for infectious surveillance into the neonatal population.
File Format	HTM / HTML
ISSN	01492918
Issue Number	3
Volume Number	37
e-ISSN	1879114X
Journal	Clinical Therapeutics
Language	English
Publisher	Elsevier
Publisher Date	2015-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Infection Diagnosis Saliva Chemistry Virus Diseases Bacterial Infections Humans Infant Infant, Newborn Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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