NDLI: Effect of Intraoperative Dexmedetomidine on Post-Craniotomy Pain.

Please wait, while we are loading the content...

Year: 2017 Volume: 39

Year: 2016 Volume: 38

Year: 2015 Volume: 37

Year: 2015 Volume: 37 Issue: 12

Year: 2015 Volume: 37 Issue: 11

Year: 2015 Volume: 37 Issue: 10

Year: 2015 Volume: 37 Issue: 9

Year: 2015 Volume: 37 Issue: 8

Year: 2015 Volume: 37 Issue: 7

Year: 2015 Volume: 37 Issue: 6

Year: 2015 Volume: 37 Issue: 5

Perioperative Pregabalin for Acute Pain After Gynecological Surgery: A Meta-analysis.

Immunogenicity of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients With Morquio A Syndrome: Results From MOR-004, a Phase III Trial.

Alternative Therapies as a Substitute for Costly Prescription Medications: Results from the 2011 National Health Interview Survey.

Effect of Intraoperative Dexmedetomidine on Post-Craniotomy Pain.

Mast Cell Activation Disease and Microbiotic Interactions.

Pharmacokinetics of Mirabegron, a ß3-Adrenoceptor Agonist for Treatment of Overactive Bladder, in Healthy East Asian Subjects.

Diabetes-Related Composite Quality End Point Attainment: Canagliflozin Versus Sitagliptin Based on a Pooled Analysis of 2 Clinical Trials.

Attitudes Toward Placebo Use in Lebanon.

Associations Between Sildenafil Use and Changes in Days of Hospitalization in a Population With Pulmonary Arterial Hypertension Associated With Connective Tissue Disease.

Novel Buccal Film Formulation of Buprenorphine-Naloxone for the Maintenance Treatment of Opioid Dependence: A 12-Week Conversion Study.

Physicians Failed to Write Flawless Prescriptions When Computerized Physician Order Entry System Crashed.

Gut Microbiota: The Conductor in the Orchestra of Immune-Neuroendocrine Communication.

The Role of Microbiota on the Gut Immunology.

Examining the Time to Therapeutic Effect of Pregabalin in Spinal Cord Injury Patients With Neuropathic Pain.

Finding Truth in a World Full of Spin: Myth-Busting in the Case of Sovaldi.

A Retrospective, Pooled Suicidality Evaluation of Ropinirole Immediate Release and Controlled Release for the Treatment of Restless Legs Syndrome.

Recent Developments and Future Directions of Pneumococcal Vaccine Recommendations.

Some Reflections on the Microbiome and Obesity.

On the Gut Microbiome-Brain Axis and Altruism.

Potential Etiologic Factors of Microbiome Disruption in Autism.

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation.

Lack of Vitamin D Receptor Causes Dysbiosis and Changes the Functions of the Murine Intestinal Microbiome.

Year: 2015 Volume: 37 Issue: 4

Year: 2015 Volume: 37 Issue: 3

Year: 2015 Volume: 37 Issue: 2

Year: 2015 Volume: 37 Issue: 1

Year: 2014 Volume: 36

Year: 2013 Volume: 35

Year: 2012 Volume: 34

Year: 2011 Volume: 33

Year: 2010 Volume: 32

Year: 2009 Volume: 31

Year: 2008 Volume: 30

Year: 2008 Volume: 30 Spec No

Year: 2008 Volume: 30 Pt 2

Year: 2007 Volume: 29

Effect of Intraoperative Dexmedetomidine on Post-Craniotomy Pain.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Peng, Ke Jin, Xiao-hong Liu, Si-lan Ji, Fu-hai
Description	Country affiliation: China Author Affiliation: Peng K ( Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, China.); Jin XH ( Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, China.); Liu SL ( Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, China.); Ji FH ( Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: jifuhaisuda@163.com.)
Abstract	PURPOSE: Pain management for patients who have undergone a craniotomy remains challenging. This study aimed to determine whether intraoperative dexmedetomidine could reduce postoperative pain, analgesic consumption, and possible adverse events in patients after craniotomy. METHODS: Eighty patients scheduled for elective supratentorial craniotomy under sevoflurane-fentanyl anesthesia were randomly allocated into two equal groups, to receive a continuous dexmedetomidine infusion of 0.5 µg/kg/h or placebo, beginning after induction and continuing until the start of skin closure. Intravenous tramadol (0.5 mg/kg) was administered to achieve an 11-point verbal rating scale (a discrete 0-10 scale) score of 4 or less in the postanesthesia care unit and, thereafter, on the ward. Pain scores, tramadol consumption, sedation scores, postoperative nausea and vomiting (PONV) scores, and other adverse events were recorded in the first 24 hours postoperatively. FINDINGS: Seventy-six patients were included in the analyses. Demographic data, surgical characteristics, and sedation levels were similar between the groups. Dexmedetomidine reduced pain scores (30 minutes, P = 0.041; 2 hours, P = 0.021) and tramadol consumption (0-2 hours, P = 0.043; 0-6 hours, P = 0.006; 0-12 hours, P = 0.023; 0-24 hours, P = 0.040) postoperatively. Dexmedetomidine also reduced PONV scores at 20, 60, 90, 120, and 240 minutes (P = 0.038, 0.022, 0.018, 0.037, 0.016, respectively). The dexmedetomidine group exhibited fewer PONV events that required treatment (P = 0.005). IMPLICATIONS: Intraoperative dexmedetomidine infusion was effective for reducing pain and analgesic consumption after craniotomy. In addition, dexmedetomidine may help to reduce PONV in patients after craniotomy treated with tramadol postoperatively. Chinese Clinical Trial Register identifier: ChiCTR-TRC-13003598.
File Format	HTM / HTML
ISSN	01492918
Issue Number	5
Volume Number	37
e-ISSN	1879114X
Journal	Clinical Therapeutics
Language	English
Publisher	Elsevier
Publisher Date	2015-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Analgesics, Non-narcotic Therapeutic Use Craniotomy Adverse Effects Dexmedetomidine Pain, Postoperative Prevention & Control Adult Aged Analgesics, Opioid Administration & Dosage Anesthesia, General Methods Conscious Sedation Double-blind Method Drug Administration Schedule Drug Therapy, Combination Female Humans Intraoperative Care Male Middle Aged Pain Management Pain Measurement Etiology Postoperative Nausea And Vomiting Prospective Studies Tramadol Young Adult Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in