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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Brzóska, Malgorzata M. Galazyn-Sidorczuk, Malgorzata Rogalska, Joanna Roszczenko, Alicja Jurczuk, Maria Majewska, Katarzyna Moniuszko-Jakoniuk, Janina |
| Description | Country affiliation: Poland Author Affiliation: Brzóska MM ( Department of Toxicology, Medical University of Bialystok, Mickiewicza 2C, Bialystok, Poland. mmbr@poczta.onet.pl) |
| Abstract | The present study was aimed at estimate, based on the rat model of human moderate and relatively high chronic exposure to cadmium (Cd), whether zinc (Zn) supplementation may prevent Cd-induced weakening in the bone biomechanical properties. For this purpose, male Wistar rats were administered Cd (5 or 50 mg/l) or/and Zn (30 or 60 mg/l) in drinking water for 6 and 12 months. Bone mineral density (BMD) and biomechanical properties (yield load, ultimate load, post-yield load, displacement at yield and at ultimate, stiffness, work to fracture, yield stress, ultimate stress and Young modulus of elasticity) of the femoral distal end and femoral diaphysis were examined. Biomechanical properties of the distal femur were estimated in a compression test, whereas those of the femoral diaphysis -- in a three-point bending test. Exposure to Cd, in a dose and duration dependent manner, decreased the BMD and weakened the biomechanical properties of the femur at its distal end and diaphysis. Zn supplementation during Cd exposure partly, but importantly, prevented the weakening in the bone biomechanical properties. The favorable Zn influence seemed to result from an independent action of this bioelement and its interaction with Cd. However, Zn supply at the exposure to Cd had no statistically significant influence on the BMD at the distal end and diaphysis of the femur. The results of the present paper suggest that Zn supplementation during exposure to Cd may have a protective influence on the bone tissue biomechanical properties, and in this way it can, at least partly, decrease the risk of bone fractures. The findings seem to indicate that enhanced dietary Zn intake may be beneficial for the skeleton in subjects chronically exposed to Cd. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Issue Number | 3 |
| Volume Number | 171 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-02-15 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Cadmium Toxicity Diaphyses Drug Effects Dietary Supplements Femur Zinc Administration & Dosage Absorptiometry, Photon Administration, Oral Animals Biomechanical Phenomena Bone Density Antagonists & Inhibitors Metabolism Disease Models, Animal Dose-response Relationship, Drug Male Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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