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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Seki, Sayaka Aoki, Miho Hosokawa, Toshiyuki Saito, Takeshi Masuma, Runa Komori, Miyako Kurasaki, Masaaki |
| Description | Country affiliation: Japan Author Affiliation: Seki S ( Environmental Adaptation Science, Division of Environmental Development, Graduate School of Environmental Science, Hokkaido University, Sapporo, Japan.) |
| Abstract | An endocrine disrupter, bisphenol-A is widely used in the production of plastics and coatings. Recently, it was reported that bisphenol-A affected neurotransmitters in the mammalian brain. On the basis of these reports, it was considered that bisphenol-A affected neuronal differentiation. In this study, the morphological changes in nerve growth factor (NFG)-induced differentiation caused by bisphenol-A were confirmed using a PC12 cell system. When a low concentration of bisphenol-A was added to medium containing NGF, it inhibited neurite extension. In addition, to clarify whether bisphenol-A affects the early and late stages of the NGF-signaling pathway in cell differentiation, changes of phosphorylation of MAP kinases and cAMP-response element binding protein (CREB) in PC12 cells treated with and without BPA in medium containing NGF were investigated using western blot analysis. As results, bisphenol-A significantly inhibited phosphorylation of CREB and ERK1/2 MAPK. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Issue Number | 1 |
| Volume Number | 194 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-10-15 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Endocrine Disruptors Toxicity Mitogen-activated Protein Kinases Antagonists & Inhibitors Neurites Drug Effects Phenols Animals Benzhydryl Compounds Blotting, Western Cell Differentiation Cells, Cultured Cyclic Amp Response Element-binding Protein Metabolism Extracellular Signal-regulated Map Kinases Nerve Growth Factor Pc12 Cells Phosphorylation Rats Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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