NDLI: Detoxification of aldehydes by histidine-containing dipeptides: from chemistry to clinical implications.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xie, Zhengzhi Baba, Shahid P. Sweeney, Brooke R. Barski, Oleg A.
Description	Country affiliation: United States Author Affiliation: Xie Z ( Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA. zhengzhi.xie@louisville.edu)
Abstract	Aldehydes are generated by oxidized lipids and carbohydrates at increased levels under conditions of metabolic imbalance and oxidative stress during atherosclerosis, myocardial and cerebral ischemia, diabetes, neurodegenerative diseases and trauma. In most tissues, aldehydes are detoxified by oxidoreductases that catalyze the oxidation or the reduction of aldehydes or enzymatic and nonenzymatic conjugation with low molecular weight thiols and amines, such as glutathione and histidine dipeptides. Histidine dipeptides are present in micromolar to millimolar range in the tissues of vertebrates, where they are involved in a variety of physiological functions such as pH buffering, metal chelation, oxidant and aldehyde scavenging. Histidine dipeptides such as carnosine form Michael adducts with lipid-derived unsaturated aldehydes, and react with carbohydrate-derived oxo- and hydroxy-aldehydes forming products of unknown structure. Although these peptides react with electrophilic molecules at lower rate than glutathione, they can protect glutathione from modification by oxidant and they may be important for aldehyde quenching in glutathione-depleted cells or extracellular space where glutathione is scarce. Consistent with in vitro findings, treatment with carnosine has been shown to diminish ischemic injury, improve glucose control, ameliorate the development of complications in animal models of diabetes and obesity, promote wound healing and decrease atherosclerosis. The protective effects of carnosine have been linked to its anti-oxidant properties, its ability to promote glycolysis, detoxify reactive aldehydes and enhance histamine levels. Thus, treatment with carnosine and related histidine dipeptides may be a promising strategy for the prevention and treatment of diseases associated with high carbonyl load.
File Format	HTM / HTML
ISSN	00092797
e-ISSN	18727786
DOI	10.1016/j.cbi.2012.12.017
Journal	Chemico-Biological Interactions
Issue Number	1-3
Volume Number	202
Language	English
Publisher	Elsevier
Publisher Date	2013-02-25
Publisher Place	Ireland
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Discipline Pharmacology Aldehydes Chemistry Metabolism Dipeptides Histidine Animals Glutathione Inactivation, Metabolic Mice Oxidation-reduction Oxidative Stress Physiology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Detoxification of aldehydes by histidine-containing dipeptides: from chemistry to clinical implications

Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls.

Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress.

Mitochondrial glutathione transport: physiological, pathological and toxicological implications.

Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease.

Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic.

The cysteine proteome.

Glutathione and redox signaling in substance abuse.

Protein carbonylation and metabolic control systems.

Detoxification of aldehydes by histidine-containing dipeptides: from chemistry to clinical implications.

Similar Documents

Detoxification of aldehydes by histidine-containing dipeptides: from chemistry to clinical implications

Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls.

Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress.

Mitochondrial glutathione transport: physiological, pathological and toxicological implications.

Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease.

Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic.

The cysteine proteome.

Glutathione and redox signaling in substance abuse.

Protein carbonylation and metabolic control systems.

Detoxification of aldehydes by histidine-containing dipeptides: from chemistry to clinical implications.