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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Victoria, Francine Novack Martinez, Débora Martins Castro, Micheli Casaril, Angela M. Alves, Diego Lenardão, Eder João Salles, Helena Domingues Schneider, Paulo H. Savegnago, Lucielli |
| Description | Country affiliation: Brazil Author Affiliation: Victoria FN ( Faculdade de Agronomia Eliseu Maciel - Departamento de Ciência e Tecnologia dos alimentos, Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil.) |
| Abstract | The antioxidant potential of organoselenium compounds has been extensively investigated because oxidative stress is a hallmark of a variety of human diseases. In this study, we report the influence of substituent groups on the antioxidant activity of (R)-Se-aryl thiazolidine-4-carboselenoate (Se-PTC) in several in vitro assays. The amino group in the thiazolidine ring affects the antioxidant activity of the compound. Our data revealed that Se-PTC a had higher radical scavenging efficiency in the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(+)) assays compared to other compounds. In the ferric ion reducing antioxidant power (FRAP) assay, Se-PTC a exhibited ferric-reducing ability at concentrations as low as 5µM. However, this effect was diminished when the amino group was protected with carbamate (Se-PTC d). In the nitric oxide scavenging assay, Se-PTC c presented better NO-scavenging than Se-PTC b. However, Se-PTC a and d did not prevent NO formation at any of the tested concentrations. Se-PTC c decreased the sodium nitroprussate-induced lipid peroxidation in the cortex and hippocampus of mice. In summary, we demonstrate that Se-PTC is a promising antioxidant compound and that the compound's activity is influenced by the amino group and by the characteristics of the arylselenium substituents. Thus, these compounds may be used as synthetic antioxidants that provide protection against oxidative diseases. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Issue Number | 2 |
| Volume Number | 205 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-09-25 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Antioxidants Chemistry Pharmacology Organoselenium Compounds Thiazolidines Animals Benzothiazoles Biphenyl Compounds Brain Drug Effects Metabolism Free Radical Scavengers Humans Lipid Peroxidation Male Mice Picrates Structure-activity Relationship Sulfonic Acids Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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