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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cuce, Gokhan Çetinkaya, Seda Koc, Tugba Esen, Haci Hasan Limandal, Cisem Balci, Tevfik Kalkan, Serpil Akoz, Mehmet |
| Description | Author Affiliation: Cuce G ( Necmettin Erbakan University Meram Medical Faculty, Histology and Embryology, Konya, Turkey. Electronic address: gokhancuce@gmail.com.); Çetinkaya S ( Necmettin Erbakan University Meram Medical Faculty, Histology and Embryology, Konya, Turkey.); Koc T ( Necmettin Erbakan University Meram Medical Faculty, Histology and Embryology, Konya, Turkey.); Esen HH ( Necmettin Erbakan University Meram Faculty of Medicine, Pathology, Konya, Turkey.); Limandal C ( Necmettin Erbakan University Meram Medical Faculty, Histology and Embryology, Konya, Turkey.); Balci T ( Necmettin Erbakan University Meram Medical Faculty, Biochemistry, Konya, Turkey.); Kalkan S ( Necmettin Erbakan University Meram Medical Faculty, Histology and Embryology, Konya, Turkey.); Akoz M ( Necmettin Erbakan University Meram Medical Faculty, Biochemistry, Konya, Turkey.) |
| Abstract | Cyclophosphamide (CP) has a range of adverse effects on liver tissue in humans and animals. Administering an antioxidant with CP might reduce such side effects. Therefore, we examined the role of vitamin E in CP-induced liver toxicity in rats. Male Wistar albino rats were divided into four groups, each of seven rats: control, CP only, CP + vitamin E, and vitamin E only groups. The rats were administered treatments intraperitoneally for 7 days. Then the serum malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) levels were determined while the livers were removed, tissue was prepared using routine histological procedures, sections were stained using hematoxylin and eosin, and the terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) method was applied. Histopathologically, CP caused hydropic degeneration, necrosis, pleomorphism, and mitotic activity. The number of TUNEL-positive cells and the MDA and ALT levels were significantly higher in the CP group. The antioxidant effects of vitamin E significantly decreased the number of TUNEL-positive cells and the ALT and MDA levels, and normalized the liver histopathology. CP induces apoptosis, has toxic effects on liver tissue, and changes the histological structure. The administration of vitamin E prevented the liver tissue damage caused by CP. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Volume Number | 232 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-05 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Drug-induced Liver Injury Prevention & Control Cyclophosphamide Adverse Effects Vitamin E Pharmacology Alanine Transaminase Blood Animals Apoptosis Drug Effects Aspartate Aminotransferases Metabolism L-lactate Dehydrogenase Liver Pathology Male Malondialdehyde Oxidative Stress Protective Agents Rats, Wistar Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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