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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ganai, Ajaz Ahmad Husain, Mohammad |
| Description | Country affiliation: India Author Affiliation: Ganai AA ( Department of Biotechnology, Jamia Millia Islamia, New Delhi, 110025, India.); Husain M ( Department of Biotechnology, Jamia Millia Islamia, New Delhi, 110025, India. Electronic address: biotechpharma2020@gmail.com.) |
| Abstract | BACKGROUND AND AIM: Genistein is a major isoflavonoid abundantly found in soy. Earlier genistein has been reported to possess protective effect against a multitude of disorders including cancer. Previously we demonstrated the protective effects of Genistein in d-Galactosamine (D-GalN) induced fulminant hepatic failure (FHF) in rats. In present study, we evaluated the hepatoprotective activity of Genistein in rat model of chronic liver damage and liver fibrosis. METHODS: Liver fibrosis was induced by intraperitoneal injection of D-GalN (250 mg/kg BW) twice a week for 12 weeks. Genistein (5 mg/kg BW) was given via intra-gastric route as co-treatment daily for 12 weeks. RESULTS: Genistein co-treatment significantly attenuated D-GalN-induced chronic liver damage and liver fibrosis as evident from a significant amelioration in functional impairment, including inhibition of the activation of Hepatic stellate cells (HSC), decreased expression in alpha smooth muscle actin ( -SMA) and accumulation of collagen matrix, and an elevation in serum alanine transaminase (ALT) and aspartate transaminase (AST) level. In addition Genistein co-treatment was associated with elevated expression of hepatic Smad7, which ultimately blunts the expression of TGF-ß and the activation of TGF-ß/Smad signaling. Furthermore Genistein significantly prevented the histopathological changes induced by D-GalN. CONCLUSION: Our results suggest that Genistein could be a novel therapeutic/nutraceutical agent in treating chronic liver damage and liver fibrosis. In addition our study also suggests a possible mechanism of action in which Smad7-induced inhibition of TGF-ß/Smad2/3 can be a central mechanism by which Genistein protects liver from chronic injury. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Journal | Chemico-Biological Interactions |
| Volume Number | 261 |
| e-ISSN | 18727786 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-11-19 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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