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Impaired prefrontal sleep spindle regulation of hippocampal-dependent learning in older adults.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mander, Bryce A. Rao, Vikram Lu, Brandon Saletin, Jared M. Ancoli-Israel, Sonia Jagust, William J. Walker, Matthew P.
Description	Author Affiliation: Mander BA ( Sleep and Neuroimaging Laboratory.); Rao V ( Sleep and Neuroimaging Laboratory.); Lu B ( Division of Pulmonary and Critical Care Medicine, California Pacific Medical Center, San Francisco, CA 94115, USA.); Saletin JM ( Sleep and Neuroimaging Laboratory.); Ancoli-Israel S ( Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.); Jagust WJ ( Helen Wills Neuroscience Institute, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.); Walker MP ( Sleep and Neuroimaging Laboratory, Helen Wills Neuroscience Institute, Department of Psychology, University of California, Berkeley, CA 94720-1650, USA.)
Abstract	A hallmark feature of cognitive aging is a decline in the ability to form new memories. Parallel to these cognitive impairments are marked disruptions in sleep physiology. Despite recent evidence in young adults establishing a role for sleep spindles in restoring hippocampal-dependent memory formation, the possibility that disrupted sleep physiology contributes to age-related decline in hippocampal-dependent learning remains unknown. Here, we demonstrate that reduced prefrontal sleep spindles by over 40% in older adults statistically mediates the effects of old age on next day episodic learning, such that the degree of impaired episodic learning is explained by the extent of impoverished prefrontal sleep spindles. In addition, prefrontal spindles significantly predicted the magnitude of impaired next day hippocampal activation, thereby determining the influence of spindles on post-sleep learning capacity. These data support the hypothesis that disrupted sleep physiology contributes to age-related cognitive decline in later life, the consequence of which has significant treatment intervention potential.
File Format	HTM / HTML
ISSN	10473211
e-ISSN	14602199
DOI	10.1093/cercor/bht188
Journal	Cerebral Cortex
Issue Number	12
Volume Number	24
Language	English
Publisher	Oxford University Press
Publisher Date	2014-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neuroscience Discipline Neurology Aging Hippocampus Physiology Memory Disorders Physiopathology Prefrontal Cortex Adolescent Brain Mapping Circadian Rhythm Evoked Potentials Image Processing, Computer-assisted Neuropsychological Tests Oxygen Blood Blood Supply Psychiatric Status Rating Scales Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience Cellular and Molecular Neuroscience

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