NDLI: Developmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex.

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Developmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Datta, Dibyadeep Arion, Dominique Lewis, David A.
Description	Country affiliation: United States Author Affiliation: Datta D ( Department of Neuroscience Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, USA.); Arion D ( Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, USA.); Lewis DA ( Department of Neuroscience Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, USA.)
Abstract	Cortical pyramidal neuron activity is regulated in part through inhibitory inputs mediated by GABAA receptors. The subunit composition of these receptors confers distinct functional properties. Thus, developmental shifts in subunit expression will likely influence the characteristics of pyramidal cell firing and the functional maturation of processes that depend on these neurons. We used laser microdissection and PCR to quantify postnatal developmental changes in the expression of GABAA receptor subunits ( 1, 2, 5, ß2, Î³2, and Î´) in layer 3 pyramidal cells of monkey prefrontal cortex, which are critical for working memory. To determine the specificity of these changes, we examined glutamate receptor subunits (AMPA Glur1 and NMDA Grin1) and conducted the same analyses in layer 5 pyramidal cells. Expression of GABAA receptor subunit mRNAs changed substantially, whereas glutamate receptor subunit changes were modest over postnatal development. Some transcripts (e.g., GABAA 1) progressively increased from birth until adulthood, whereas others (e.g., GABAA 2) declined with age. Changes in some transcripts were present in only one layer (e.g., GABAA Î´). The development of GABAA receptor subunit expression in primate prefrontal pyramidal neurons is protracted and subunit- and layer-specific. These trajectories might contribute to the molecular basis for the maturation of working memory.
File Format	HTM / HTML
ISSN	10473211
e-ISSN	14602199
DOI	10.1093/cercor/bhu040
Journal	Cerebral Cortex
Issue Number	8
Volume Number	25
Language	English
Publisher	Oxford University Press
Publisher Date	2015-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neuroscience Discipline Neurology Prefrontal Cortex Growth & Development Metabolism Pyramidal Cells Receptors, Gaba-a Aging Animals Laser Capture Microdissection Macaca Mulatta Rna, Messenger Real-time Polymerase Chain Reaction Receptors, Ampa Receptors, N-methyl-d-aspartate Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience Cellular and Molecular Neuroscience

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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