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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Welsh, Rober C. Sauriol, Luc Zhang, Zugui Kolm, Paul Weintraub, Willian S. Theroux, Pierre |
| Spatial Coverage | Canada |
| Description | Country affiliation: Canada Author Affiliation: Welsh RC ( University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Canada. rwelsh@cha.ab.ca) |
| Abstract | OBJECTIVE: To evaluate the cost-effectiveness of enoxaparin versus unfractionated heparin in conjunction with fibrinolysis in ST elevation myocardial infarction patients within Canada. DESIGN: Based on the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment - Thrombolysis in Myocardial Infarction (ExTRACT-TIMI) 25 trial, a model was created to analyze the cost-effectiveness of enoxaparin compared with unfractionated heparin in conjunction with fibrinolysis among ST elevation myocardial infarction patients within Canada. Clinical outcomes were derived from published results of the main trial. Resource use costs were first assessed based on United States Diagnosis-Related Group values for hospitalizations and Current Procedural Terminology codes for outpatient visits and tests. Both were then converted using Canadian local costs. Survival and life expectancy were estimated from Framingham survival data. The incremental cost-effectiveness ratio was expressed as cost per life year gained. RESULTS: Through 30 days after random assignment, the primary composite end point favoured the enoxaparin group over the unfractionated heparin group (death or recurrent myocardial infarction rate 9.9% versus 12.0%, P<0.001), and was associated with a modest increased cost of \$169.50 (\$8,757.00 versus \$8,587.50, respectively). Life years gained as a result of treatment with enoxaparin was increased by 0.11 years (P<0.05). Enoxaparin was found to be cost-effective, as indicated by an incremental cost-effectiveness ratio of \$4,930 with a 99% probability of costing less than \$20,000. CONCLUSIONS: Although associated with modest increased direct medication costs, enoxaparin following fibrinolysis improved the clinical efficacy in STEMI patients and increased the life years gained. |
| File Format | HTM / HTML |
| ISSN | 0828282X |
| e-ISSN | 19167075 |
| Journal | Canadian Journal of Cardiology |
| Issue Number | 12 |
| Volume Number | 25 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Cardiology Anticoagulants Enoxaparin Heparin Myocardial Infarction Administration & Dosage Canada Cost-benefit Analysis Double-blind Method Fibrinolysis Health Care Costs Statistics & Numerical Data Drug Therapy Multicenter Study Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
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