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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jewo, P. I. Duru, F. I. Fadeyibi, I. O. Saalu, L. C. Noronha, C. C. |
| Description | Country affiliation: Nigeria Author Affiliation: Jewo PI ( Department of Anatomy, Lagos State University College of Medicine, PMB 21266, Ikeja, Lagos, Nigeria. petkutajewo07@yahoo.co.uk) |
| Abstract | OBJECTIVE: To investigate the ability of ascorbic acid to protect the testes from damage in severe burns. DESIGN: Experimental study. SETTING: University of Lagos Medical School, Department of Anatomy. ANIMALS: 28 adult male Wistar rats (250-300 g). INTERVENTION: Third degree burn was induced on 40% body surface area of rats and they were given ascorbic acid at 4 mg/kg over 8 weeks. MAIN OUTCOME MEASURED: Weight of reproductive organs and epididymal sperm parameters were measured. Oxidative status was assayed and a semi-quantitative assessment of histologic changes was also carried out. RESULTS: Burn caused severe seminiferous tubular damage, especially germ cell loss (p<0.05). This was matched by significant reduction in sperm density and morphology (p<0.05). Burn also increased oxidative stress, with elevated malondialdehyde (MDA) levels (p<0.01) and changes in catalase and superoxide dismutase enzyme levels. Ascorbic acid prevented the changes in all sperm parameters. It normalized MDA levels (p<0.01) and attenuated changes in the levels of catalase and superoxide dismutase. Ascorbic acid treatment also significantly reduced histologic damage to seminiferous tubules. CONCLUSION: This study shows that severe thermal injury causes significant testicular damage and impairs spermatogenesis. It also shows that ascorbic acid protects the testis from such damage and therefore has the potential to be a useful adjunct therapy during treatment of young males with severe burns. |
| File Format | HTM / HTML |
| ISSN | 03054179 |
| Issue Number | 1 |
| Volume Number | 38 |
| e-ISSN | 18791409 |
| Journal | Burns |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Traumatology Antioxidants Therapeutic Use Ascorbic Acid Testis Injuries Animals Burns Catalase Metabolism Male Malondialdehyde Oxidative Stress Drug Effects Rats Rats, Wistar Seminiferous Tubules Pathology Sperm Motility Spermatogenesis Spermatozoa Cytology Superoxide Dismutase Testosterone Blood Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine Surgery Critical Care and Intensive Care Medicine |
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