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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wu, Ai-Hua Huang, Yu-ling Zhang, Lan-Zhen Tian, Geng Liao, Qiong-Zhi Chen, Shi-Ling |
| Description | Author Affiliation: Wu AH ( Institute of Gynecology and Obstetrics, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, People's Republic of China); Huang YL ( Center for Reproductive Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, People's Republic of China); Zhang LZ ( Institute of Gynecology and Obstetrics, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, People's Republic of China.); Tian G ( Institute of Gynecology and Obstetrics, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, People's Republic of China.); Liao QZ ( Center for Reproductive Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, People's Republic of China.); Chen SL ( Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China. Electronic address: shilingchendr@163.com.) |
| Abstract | Ovarian cancer (OC) remains one of the most common types of malignant cancer, and the molecular mechanism underlying its proliferation is still largely unclear. It is reported that microRNAs acted as important regulators of cell proliferation by regulating its targeted gene. In this study, our result showed that miR-572 was markedly upregulated in OC cell lines and clinical tissues. Results of both gain-of-function and loss-of-function experiments revealed that upregulation of miR-572 expression dramatically promoted OC cell proliferation, whereas decreased miR-572 expression significantly reduced cell proliferation. Bioinformatics analysis and luciferase reporter assays further revealed PPP2R2C, a putative tumor suppressor as a potential target of miR-572. Moreover, silencing of PPP2R2C using small interfering RNA (siRNA) counteracted the proliferation arrest by miR-572-in in OC cells. In sum, our data provide that miR-572 promoted cell proliferation in OC by targeting PPP2R2C and might serve as a therapeutic target of OC. |
| File Format | HTM / HTML |
| ISSN | 07533322 |
| Volume Number | 77 |
| e-ISSN | 19506007 |
| Journal | Biomedicine & Pharmacotherapy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-02-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Micrornas Genetics Ovarian Neoplasms Protein Phosphatase 2 Cell Line, Tumor Cell Proliferation Female Gene Expression Regulation, Neoplastic Humans Real-time Polymerase Chain Reaction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Pharmacology |
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