NDLI: Long noncoding RNA BDNF-AS regulates ketamine-induced neurotoxicity in neural stem cell derived neurons.

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Long noncoding RNA BDNF-AS regulates ketamine-induced neurotoxicity in neural stem cell derived neurons.

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Long noncoding RNA BDNF-AS regulates ketamine-induced neurotoxicity in neural stem cell derived neurons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zheng, Xiaozhu Lin, Chunshui Li, Yuhong Ye, Jing Zhou, Jiali Guo, Peipei
Description	Country affiliation: China Author Affiliation: Zheng X ( Department of anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China); Lin C ( Department of anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: lcs6678@aol.com.); Li Y ( Department of anesthesiology, Shaoxing Pepople's Hospital, Shaoxing, 312300, China.); Ye J ( Department of anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.); Zhou J ( Department of anesthesiology, Zhejiang Hospital, Hangzhou, 310002, China.); Guo P ( Department of anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.)
Abstract	BACKGROUND: Ketamine is an anesthetic commonly used in both humans and animals. Emerging evidence has demonstrated that ketamine may induce neurotoxicity in neural stem cell-derived neurons. In this work, we investigated whether long noncoding RNA (lncRNA) Brain derived neurotrophic factor antisense (BDNF-AS) was involved in ketamine-induced neurotoxicity in differentiation of mouse embryonic neural stem cells. METHODS: Mouse embryonic neural stem cells were differentiated in vitro, and treated with ketamine. The corresponding change in gene expression levels of BDNF and BDNF-AS were assessed by qRT-PCR. BDNF-AS was subsequently downregulated by siRNA. And its effect on protecting neuronal apoptosis, promoting neurite regrowth, and activating TrkB signaling pathways were assessed by TUNEL assay, neurite outgrowth assay, and western blot assay, respectively. RESULTS: In ketamine-injured mouse embryonic neural stem cell-derived neurons, BDNF was downregulated, whereas BDNF-AS was upregulated in dose-dependent manner. SiRNA-mediated BDNF-AS downregulation ameliorated neuronal apoptosis, induced neurite outgrowth, and phosphorylated TrkB signaling pathway after ketamine-induce neurotoxicity in mouse embryonic neural stem cell-derived neurons. CONCLUSIONS: Inhibition of BDNF-AS is a novel method to protect ketamine-induced neurotoxicity in mouse embryonic neural stem cell-derived neurons, very likely through the activation of TrkB signaling pathway.
File Format	HTM / HTML
ISSN	07533322
Journal	Biomedicine & Pharmacotherapy
Volume Number	82
e-ISSN	19506007
Language	English
Publisher	Elsevier
Publisher Date	2016-08-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

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