NDLI: Biopartitioning micellar chromatography separation methods: modelling quantitative retention-activity relationships of cephalosporins.

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Biopartitioning micellar chromatography separation methods: modelling quantitative retention-activity relationships of cephalosporins.

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Biopartitioning micellar chromatography separation methods: modelling quantitative retention-activity relationships of cephalosporins.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Li-Ping Ye, Li-Ming Chen, Cong Wu, Jia-Qi Chen, Yu
Description	Author Affiliation: Wu LP ( West China School of Pharmacy, Sichuan University, Chengdu, 610041, People's Republic of China.)
Abstract	In this article, recent applications of chromatographic systems, particularly biopartitioning micellar chromatography (BMC) systems based on amphiphilic structures, have been reported. The aim is to take a look at the capability of quantitative retention-activity relationship (QRAR) models with BMC to describe and/or estimate the bioactivity of cephalosporins. Better qualification of BMC systems was obtained according to the octanol-water partition coefficient (log P); the bioactivity parameters (Lag-T, T(1/2beta), F%, T(1/a), P%, AUC and C(max)) were correlated with the retention factors of cephalosporins processed by Alltech-chromstation software, and the classical data were compared with the predictive values based on QRAR models. The results indicate that using only one descriptor (the retention factor, k) to explain the pharmacokinetic and pharmacodynamic properties of cephalosporins is adequate, and this in vitro approach is an advanced tool for pharmacodynamics research.
File Format	HTM / HTML
ISSN	02693879
Issue Number	6
Volume Number	22
e-ISSN	10990801
Journal	Biomedical Chromatography
Language	English
Publisher	Wiley
Publisher Date	2008-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Chemistry Discipline Molecular Biology Discipline Biochemistry Discipline Pharmacology Chromatography, Liquid Methods Models, Theoretical Hydrogen-ion Concentration Micelles Quantitative Structure-activity Relationship Spectrophotometry, Ultraviolet Structure-activity Relationship Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Analytical Chemistry Drug Discovery Clinical Biochemistry Biochemistry Molecular Biology Pharmacology

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