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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xiang, Yi Zhou, Liping Qian, Zhenyu Peng, Kelong Li, Dongyan Chen, Xiaomei Jiang, Hongliang Zheng, Heng |
| Description | Country affiliation: China Author Affiliation: Xiang Y ( College of Pharmacy, Tongji Medical Colllege, Huazhong University of Science and Technology, Wuhan 430030, China.) |
| Abstract | A sensitive, rapid and simple liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS/MS) method was developed for the quantitative determination of cyclobenzaprine in human plasma, to study the pharmacokinetic behavior of cyclobenzaprine capsule in healthy Chinese volunteers. With escitalopram as the internal standard (IS), sample pretreatment involved a one-step liquid-liquid extraction using saturated sodium carbonate solution and hexane-diethyl ether (3:1, v/v). The separation was performed on an Ultimate XB-CN column (150 × 2.1 mm, 5 µm). Isocratic elution was applied using acetonitrile-water (40:60, v/v) containing 10 m M ammonium acetate and 0.1% formic acid. The detection was carried out on a triple-quadrupole tandem mass spectrometer in multiple reaction monitoring mode via electrospray ionization. The ion-pairs including m/z 276.2-216.2 for cyclobenzaprine and m/z 325.2-109.1 for IS were used for monitoring. Linear calibration curves were obtained over the range of 0.049-29.81 ng/mL with the lower limit of quantification at 0.049 ng/mL. The intra- and inter-day precision showed ≤ 6.5% relative standard deviation. The established method laid the groundwork for follow-up studies and provided basis for the clinical administration of cyclobenzaprine. |
| File Format | HTM / HTML |
| ISSN | 02693879 |
| Issue Number | 9 |
| Volume Number | 26 |
| e-ISSN | 10990801 |
| Journal | Biomedical Chromatography |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Discipline Molecular Biology Discipline Biochemistry Discipline Pharmacology Amitriptyline Analogs & Derivatives Chromatography, Liquid Methods Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry Blood Chemistry Isolation & Purification Pharmacokinetics Citalopram Drug Stability Humans Linear Models Liquid-liquid Extraction Male Reproducibility Of Results Sensitivity And Specificity Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Analytical Chemistry Drug Discovery Clinical Biochemistry Biochemistry Molecular Biology Pharmacology |
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