NDLI: A sensitive and selective LC-MS/MS method for the quantitative determination of segetalin A from the plasma of rats.

Please wait, while we are loading the content...

Determination of the chemical constituents of the different processed products of Anemarrhena asphodeloides Rhizomes by high-performance liquid chromatography quadrupole time-of-flight mass spectrometry.

A rapid UPLC-MS/MS method for the determination of oleanolic acid in rat plasma and liver tissue: application to plasma and liver pharmacokinetics.

Stability of ubiquinol-10 (reduced form of coenzyme Q10 ) in human blood.

Evaluation of the influence of salt processing on pharmacokinetics of psoralen and isopsoralen in Psoralea corylifolia L.

Assessment of pharmacokinetic interaction between piracetam and l-carnitine in healthy subjects.

Cell extraction combined with off-line HPLC for screening active compounds from Coptis chinensis.

Development of a functional assay to detect inhibitors of Plasmodium falciparum glutathione reductase utilizing liquid chromatography-mass spectrometry.

Relationships between structure, ionization profile and sensitivity of exogenous anabolic steroids under electrospray ionization and analysis in human urine using liquid chromatography–tandem mass spectrometry

Preparation of core–shell structure $Fe_{3}O_{4}@SiO_{2}$ superparamagnetic microspheres immoblized with iminodiacetic acid as immobilized metal ion affinity adsorbents for His-tag protein purification

Quantification of mequitazine in human plasma by gas chromatography- quadrupole mass spectrometry and its application to a human pharmacokinetic study.

The difference between blood-associated and water-associated herbs of Danggui-Shaoyao San in theory of TCM, based on serum pharmacochemistry.

Application of liquid chromatographic/tandem mass spectrometric method to a urinary excretion study of subutinib and active metabolite in human urine.

Polyphenolic profile and antioxidant effects of various parts of Artemisia annua L.

Sensitive determination of glucose in Dulbecco's modified Eagle medium by high-performance liquid chromatography with 1-phenyl-3-methyl-5-pyrazolone derivatization: application to gluconeogenesis studies.

A sensitive and selective LC-MS/MS method for the quantitative determination of segetalin A from the plasma of rats.

Qualification and application of a liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of trastuzumab in rat plasma.

Development and validation of a rapid LC-MS/MS method to quantify letrozole in human plasma and its application to therapeutic drug monitoring.

Quantitative analysis of histone H3 and H4 post-translational modifications in doxorubicin-resistant leukemia cells

Pharmacokinetics of tecomin in rats after intragastric and intravenous administration.

Letter to the editor regarding 'Development and validation of a sensitive UHPLC-MS/MS method for simultaneous analysis of tramadol, dextromethorphan chlorpheniramine and their major metabolites in human plasma in forensic context: application to pharmacokinetics'.

Quantitative determination of pravastatin and its metabolite 3 -hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS.

Monitoring of biogenic amines and drugs of various therapeutic groups in urine samples with use of HPLC.

A rapid and sensitive LC-MS/MS method for the determination of linarin in small-volume rat plasma and tissue samples and its application to pharmacokinetic and tissue distribution study.

Development of easy-to-use reverse-phase liquid chromatographic methods for determining PRE-084, RC-33 and RC-34 in biological matrices. The first step for in vivo analysis of sigma1 receptor agonists.

Year: 2016 Volume: 30 Issue: 3

Year: 2016 Volume: 30 Issue: 2

Year: 2016 Volume: 30 Issue: 1

Year: 2015 Volume: 29

Year: 2014 Volume: 28

Year: 2013 Volume: 27

Year: 2012 Volume: 26

Year: 2011 Volume: 25

Year: 2010 Volume: 24

Year: 2009 Volume: 23

Year: 2008 Volume: 22

Year: 2007 Volume: 21

A sensitive and selective LC-MS/MS method for the quantitative determination of segetalin A from the plasma of rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Jianmeng Zhang, Nan Pang, Li Xu, Dahai Yan, Weiwei Wu, Jiang Chen, Haiyan
Description	Country affiliation: China Author Affiliation: Wang J ( Gereology Department, First Hospital of Jilin University, Changchun, 130021, China.); Zhang N ( Emergency Department, First Hospital of Jilin University, Changchun, 130021, China.); Pang L ( Emergency Department, First Hospital of Jilin University, Changchun, 130021, China.); Xu D ( Emergency Department, First Hospital of Jilin University, Changchun, 130021, China.); Yan W ( Emergency Department, First Hospital of Jilin University, Changchun, 130021, China.); Wu J ( Neurology Department, First Hospital of Jilin University, Changchun, 130021, China.); Chen H ( Gereology Department, First Hospital of Jilin University, Changchun, 130021, China.)
Abstract	A sensitive and selective LC-MS/MS method was developed and validated for the determination and pharmacokinetic investigation of segetalin A in rat plasma. Sample preparation was accomplished through a simple SPE procedure for the removal and preconcentration of the analyte and IS. Plasma samples were separated by HPLC on a Symmetry C18 column using a mobile phase consisting of methanol and 0.1% formic acid in water (70:30, v/v) with isocratic elution. The quantification was performed using multiple reaction monitoring with the transitions m/z 610.3 â 511.2 for segetalin A and m/z 779.4 â 751.4 for IS, respectively. The calibration curve was linear over the range of 8.0-4000 ng/mL with a limit of quantitation (LOQ) of 8.0 ng/mL. This method was applied in a pharmacokinetic study of segetalin A in rats. For intravenous (i.v.) administration, the plasma concentrations of segetalin A decreased quickly (t1/2z, 1.31 ± 0.341 h). For oral administration, the plasma concentrations of segetalin A increased to a peak value at 1.50 ± 0.577 h, followed by a gradual decrease to the LOQ in 12 h. The mean AUC values after i.v. and oral administration were 553 ± 105 and 1482 ± 110 ng h/mL, respectively.
File Format	HTM / HTML
ISSN	02693879
Issue Number	4
Volume Number	30
e-ISSN	10990801
Journal	Biomedical Chromatography
Language	English
Publisher	Wiley
Publisher Date	2016-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Chemistry Discipline Molecular Biology Discipline Biochemistry Discipline Pharmacology Chromatography, High Pressure Liquid Methods Peptides, Cyclic Blood Tandem Mass Spectrometry Administration, Oral Animals Limit Of Detection Administration & Dosage Rats Rats, Wistar Reproducibility Of Results Solid Phase Extraction Journal Article Validation Studies
Content Type	Text
Resource Type	Article
Subject	Medicine Analytical Chemistry Drug Discovery Clinical Biochemistry Biochemistry Molecular Biology Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

LC-ESI-MS/MS analysis and pharmacokinetics of heterophyllin B, a cyclic octapeptide from Pseudostellaria heterophylla in rat plasma.

A rapid and sensitive LC-MS/MS method for quantification of 3,29-dibenzoyl rarounitriol in rat plasma: application to a pharmacokinetic study.

Highly sensitive method for the determination of adenosine by LC-MS/MS-ESI: method validation and scope of application to a pharmacokinetic/pharmacodynamic study.

A rapid and sensitive LC-MS/MS method for the determination of osthole in rat plasma: application to pharmacokinetic study.

A simple and sensitive LC-MS/MS method for the determination of sotalol in rat plasma

Development and validation of a sensitive and selective LC-MS/MS method for determination of tacrolimus in oral fluids.

LC-ESI-MS/MS analysis of quercetin in rat plasma after oral administration of biodegradable nanoparticles.

Simultaneous determination and pharmacokinetic study of three isoflavones from Trifolium pratense extract in rat plasma by LC-MS/MS.

Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of nobiletin in rat plasma: application to a pharmacokinetic study.

A sensitive and selective LC-MS/MS method for the quantitative determination of segetalin A from the plasma of rats.

Similar Documents

LC-ESI-MS/MS analysis and pharmacokinetics of heterophyllin B, a cyclic octapeptide from Pseudostellaria heterophylla in rat plasma.

A rapid and sensitive LC-MS/MS method for quantification of 3,29-dibenzoyl rarounitriol in rat plasma: application to a pharmacokinetic study.

Highly sensitive method for the determination of adenosine by LC-MS/MS-ESI: method validation and scope of application to a pharmacokinetic/pharmacodynamic study.

A rapid and sensitive LC-MS/MS method for the determination of osthole in rat plasma: application to pharmacokinetic study.

A simple and sensitive LC-MS/MS method for the determination of sotalol in rat plasma

Development and validation of a sensitive and selective LC-MS/MS method for determination of tacrolimus in oral fluids.

LC-ESI-MS/MS analysis of quercetin in rat plasma after oral administration of biodegradable nanoparticles.

Simultaneous determination and pharmacokinetic study of three isoflavones from Trifolium pratense extract in rat plasma by LC-MS/MS.

Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of nobiletin in rat plasma: application to a pharmacokinetic study.

A sensitive and selective LC-MS/MS method for the quantitative determination of segetalin A from the plasma of rats.