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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Flores-Santana, Wilmarie Switzer, Christopher Ridnour, Lisa A. Basudhar, Debashree Mancardi, Daniele Donzelli, Sonia Thomas, Douglas D. Miranda, Katrina M. Fukuto, Jon M. Wink, David A. |
| Description | Country affiliation: United States Author Affiliation: Flores-Santana W ( Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.) |
| Abstract | For the past couple of decades nitric oxide (NO) and nitroxyl (HNO) have been extensively studied due to the important role they play in many physiological and/or pharmacological processes. Many researchers have reported important signaling pathways as well as mechanisms of action of these species, showing direct and indirect effects depending on the environment. Both NO and HNO can react with, among others, metals, proteins, thiols and heme proteins via unique and distinct chemistry leading to improvement of some clinical conditions. Understanding the basic chemistry of NO and HNO and distinguishing their mechanisms of action as well as methods of detection are crucial for understanding the current and potential clinical applications. In this review, we summarize some of the most important findings regarding NO and HNO chemistry, revealing some of the possible mechanisms of their beneficial actions. |
| File Format | HTM / HTML |
| ISSN | 02536269 |
| Issue Number | 8 |
| Volume Number | 32 |
| e-ISSN | 19763786 |
| Journal | Archives of Pharmacal Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2009-08-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Nitric Oxide Chemistry Nitrogen Oxides Animals Humans Physiology Metabolism Reactive Nitrogen Species Comparative Study Journal Article Research Support, N.i.h., Intramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine |
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