NDLI: Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats.

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Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qiang, Li-Qin Wang, Cai-Ping Wang, Fu-Meng Pan, Ying Yi, Li-Tao Zhang, Xian Kong, Ling-Dong
Description	Author Affiliation: Qiang LQ ( State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, People's Republic of China.)
Abstract	Magnolia bark combined with ginger rhizome is a common drug pair in traditional Chinese prescriptions for the treatment of depression. In the present study, we examined antidepressant-like effects of the mixture of honokiol and magnolol (HMM) from magnolia bark and essential oil from ginger rhizome (OGR) alone and in combination in chronic unpredictable mild stress (CUMS) of rats. Behavioral (sucrose intake, immobility time of forced swimming test) and biochemical parameters [serotonin (5-HT) in prefrontal cortex, hippocampus, and striatum, gastric mucosa cholecystokinin (CCK) and serum gastrin (GAS) levels] were simultaneously examined in the CUMS rats. 20 mg/kg HMM alone, but not OGR, significantly increased sucrose intake and reduced immobility time in the CUMS rats. Moreover, 20 mg/kg HMM and 14 mg/kg OGR in combination exhibited significant synergistic effects on sucrose intake increase and immobility time reduction in the CUMS rats. HMM elevated 5-HT levels in various brain regions, and OGR reduced gastric mucosa CCK and serum GAS levels in the CUMS rats. These results suggested that the synergistic antidepressant-like effects of compatibility of HMM with OGR might be mediated simultaneously by regulation of the serotonergic and gastroenteric system functions. These findings also provided a pharmacological basis for the clinical application of this drug pair of magnolia bark and ginger rhizome in traditional Chinese medicine.
File Format	HTM / HTML
ISSN	02536269
Issue Number	9
Volume Number	32
e-ISSN	19763786
Journal	Archives of Pharmacal Research
Language	English
Publisher	Springer
Publisher Date	2009-09-01
Publisher Place	Korea (South)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Antidepressive Agents Pharmacology Biphenyl Compounds Ginger Lignans Oils, Volatile Animals Administration & Dosage Brain Drug Effects Cholecystokinin Analysis Depression Drug Therapy Drug Synergism Drug Therapy, Combination Gastric Mucosa Chemistry Gastrins Blood Male Rats Rats, Wistar Serotonin Swimming Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine

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Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats.