NDLI: Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice.

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Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice.

Year: 2010 Volume: 33 Issue: 1

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Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Sung Hee Choung, Se Young
Description	Author Affiliation: Kim SH ( Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea.)
Abstract	In previous study, the anti-diabetic effect of Cinnamomi Cassiae extract (Cinnamon bark: Lauraceae) in a type II diabetic animal model (C57BIKsj db/db) has been reported. To explore their mechanism of action, in present study, the effect of cinnamon extract on anti-hyperglycemia and anti-hyperlipidemia was evaluated by measuring the blood glucose levels, serum insulin, and adiponectin levels, serum and hepatic lipids, PPARalpha mRNA expression in liver and PPARgamma mRNA expression in adipose tissue, respectively. Male C57BIKs db/db mice were divided into a diabetic group and cinnamon extract treated group and examined for a period of 12 weeks (200 mg/kg, p.o). The fasting blood glucose and postprandial 2 h blood glucose levels in the cinnamon treated group were significantly lower than those in the control group (p < 0.01), whereas the serum insulin and adiponectin levels were significantly higher in the cinnamon treated group than in the control group (p < 0.05). The serum lipids and hepatic lipids were improved in the cinnamon administered group. Also the PPARalpha mRNA (liver) and PPARgamma mRNA (adipose tissue) expression levels were increased significantly in the cinnamon treated group (p < 0.05). Our results suggest that cinnamon extract significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism.
File Format	HTM / HTML
ISSN	02536269
Issue Number	2
Volume Number	33
e-ISSN	19763786
Journal	Archives of Pharmacal Research
Language	English
Publisher	Springer
Publisher Date	2010-02-01
Publisher Place	Korea (South)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Cinnamomum Diabetes Mellitus, Experimental Drug Therapy Hypoglycemic Agents Therapeutic Use Hypolipidemic Agents Phytotherapy Plant Extracts Pharmacology Abdominal Fat Drug Effects Metabolism Adiponectin Blood Animals Blood Glucose Body Weight Cholesterol Cinnamates Analysis Insulin Liver Anatomy & Histology Male Mice Mice, Inbred C57bl Mice, Mutant Strains Ppar Alpha Ppar Gamma Plant Bark Chemistry Triglycerides Journal Article
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine

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