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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Potluri, Raja Hemanth Kumar Bandari, Suresh Jukanti, Raju Veerareddy, Prabhakar Reddy |
| Description | Country affiliation: India Author Affiliation: Potluri RH ( Department of Pharmaceutics and Industrial Pharmacy, St. Peter's Institute of Pharmaceutical Sciences, Vidyanagar, Warangal, AP, India.) |
| Abstract | The objective of the study was enhancement of dissolution of poorly soluble carvedilol by solid dispersions (SDs) with Gelucire 50/13 using solvent evaporation method. The solubility of carvedilol showed linear increase with increasing concentrations of Gelucire indicating A(L) type solubility diagrams. SDs characterized for physicochemical characteristics using differential scanning calorimetry and X-ray diffractometry revealed transformation of crystalline form of drug to amorphous form which was confirmed by scanning electron micrographs. Further fourier transform infrared spectroscopy results suggested there is no drug carrier interaction. From the dissolution parameters such as mean dissolution time, dissolution efficiency and drug release rate, improved dissolution characteristics for SDs were observed compared with physical mixture and pure drug. Thus SDs of carvedilol in Gelucire 50/13 showed enhanced solubility and dissolution rate compared to pure drug. |
| File Format | HTM / HTML |
| ISSN | 02536269 |
| Issue Number | 1 |
| Volume Number | 34 |
| e-ISSN | 19763786 |
| Journal | Archives of Pharmacal Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2011-01-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antihypertensive Agents Chemistry Carbazoles Drug Carriers Fats Oils Propanolamines Administration & Dosage Calorimetry, Differential Scanning Crystallization Microscopy, Electron, Scanning Solubility X-ray Diffraction Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine |
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