NDLI: Anti-inflammatory activity of sappanchalcone isolated from Caesalpinia sappan L. in a collagen-induced arthritis mouse model.

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Anti-inflammatory activity of sappanchalcone isolated from Caesalpinia sappan L. in a collagen-induced arthritis mouse model.

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Anti-inflammatory activity of sappanchalcone isolated from Caesalpinia sappan L. in a collagen-induced arthritis mouse model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jung, Eui-Gil Han, Kook-Il Kwon, Hyun-Jung Patnaik, Bharat Bhusan Kim, Wan-Jong Hur, Gang Min Nam, Kung-Woo Han, Man-Deuk
Description	Author Affiliation: Jung EG ( Department of Life Science and Biotechnology, Soonchunhyang University, Asan, Chungnam, 336-745, Republic of Korea.)
Abstract	Sappanchalcone, a bioactive flavonoid isolated from the heartwood of Caesalpinia sappan L. possesses anti-inflammatory effects. We studied the efficacy of sappanchalcone in attenuating collagen-induced arthritis (CIA) in a mouse model of rheumatoid arthritis. Sappanchalcone was purified to homogeneity from the chloroform fraction of the methanolic extract of C. sappan, and identified using mass spectrometry and (1)H-nuclear magnetic resonance spectroscopy. CIA-induced male DBA/1J mice were divided into control, sappanchalcone-treated, and methotrexate-treated groups (n = 10 per group). Paw swelling, arthritis severity, radiographic and histomorphometric changes were assessed to measure the protective role of sappanchalcone against chronic disease progression. Sappanchalcone administration significantly reduced clinical arthritis and inflammatory edema in paws. Bone mineral density and trabecular structure were maintained in CIA mice administered sappanchalcone. The levels of pro-inflammatory cytokines (TNF- , IL-6, and 1L-1ß) were significantly lower in the serum of sappanchalcone-treated mice as compared with the control group. Our results suggest that sappanchalcone could be used as an anti-inflammatory and bone-protective agent during the treatment of rheumatoid arthritis.
File Format	HTM / HTML
ISSN	02536269
Issue Number	6
Volume Number	38
e-ISSN	19763786
Journal	Archives of Pharmacal Research
Language	English
Publisher	Springer
Publisher Date	2015-06-01
Publisher Place	Korea (South)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Anti-inflammatory Agents, Non-steroidal Isolation & Purification Pharmacology Arthritis, Experimental Drug Therapy Caesalpinia Chemistry Chalcones Collagen Animals Chemically Induced Pathology Bone Density Drug Effects Bone And Bones Cytokines Metabolism Edema Enzymes Foot Magnetic Resonance Spectroscopy Male Mass Spectrometry Mice Mice, Inbred Dba Plant Extracts Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine

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