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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Marie, Benjamin Huet, Hélène Marie, Arul Djediat, Chakib Puiseux-Dao, Simone Catherine, Arnaud Trinchet, Isabelle Edery, Marc |
| Description | Country affiliation: France Author Affiliation: Marie B ( UMR 7245 CNRS Molécules de Communication et Adaptation des Microorganismes, Équipe Cyanobactéries, Cyanotoxines et Environnement, Muséum National d'Histoire Naturelle, 12 Rue Buffon, F-75231 Paris Cedex 05, France.) |
| Abstract | Cyanobacterial toxic blooms often occur in freshwater lakes and constitute a potential health risk to human populations, as well as to fish and other aquatic organisms. Microcystin-LR (the cyanotoxin most commonly detected in the freshwater environment) is a potent hepatotoxin, deregulating the kinase pathway by inhibiting phosphatases 1 and 2A. Although toxicological effects have been clearly linked to the in vitro exposure of fish to purified microcystins, cyanotoxins are produced by the cyanobacteria together with numerous other potentially toxic molecules, and their overall and specific implications for the health of fish have still not been clearly established and remain puzzlingly difficult to assess. The medaka fish (Oryzias latipes) was chosen as an in vitro model for studying the effects of a cyanobacterial bloom on liver protein contents using a gel free quantitative approach, iTRAQ, in addition to pathology examinations on histological preparations. Fish were gavaged with 5 µL cyanobacterial extracts (Planktothrix agardhii) from a natural bloom (La Grande Paroisse, France) containing 2.5 µg equiv. MC-LR. 2h after exposure, the fish were sacrificed and livers were collected for analysis. Histological observations indicate that hepatocytes present glycogen storage loss, and cellular damages, together with immunological localization of MCs. Using a proteomic approach, 304 proteins were identified in the fish livers, 147 of them with a high degree of identification confidence. Fifteen of these proteins were statistically significantly different from those of controls (gavaged with water only). Overall, these protein regulation discrepancies clearly indicate that oxidative stress and lipid regulation had occurred in the livers of the exposed medaka fish. In contrast to previous pure microcystin-LR gavage experiments, marked induction of vitellogenin 1 protein was observed for the first time with a cyanobacterial extract. This finding was confirmed by ELISA quantification of vitellogenin liver content, suggesting that the Planktothrix bloom extract had induced the occurrence of an endocrine-disrupting effect. |
| File Format | HTM / HTML |
| ISSN | 0166445X |
| Volume Number | 114-115 |
| e-ISSN | 18791514 |
| Journal | Aquatic Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Drug-induced Liver Injury Veterinary Cyanobacteria Chemistry Fish Diseases Chemically Induced Gene Expression Regulation Drug Effects Microcystins Toxicity Oryzias Metabolism Animals Pathology Liver Controlled Clinical Trial Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Aquatic Science |
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