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Underexpression and overexpression of Fas and Fas ligand: a double-edged sword.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Randhawa, Shahid R. Chahine, Bassem G. Lowery-Nordberg, Mary Cotelingam, James D. Casillas, Adrian M.
Description	Country affiliation: United States Author Affiliation: Randhawa SR ( Department of Pediatrics, Section of Allergy and Immunology, LSU Health Sciences Center, Shreveport, Louisiana 71130, USA.)
Abstract	OBJECTIVE: To compare autoimmune lymphoproliferative syndrome (ALPS) and Stevens-Johnson syndrome (SJS) with respect to the defects in Fas- and Fas ligand (FasL)-mediated apoptosis. DATA SOURCES: Selected reviews, case reports, and original studies were searched in PubMed and MEDLINE for the keywords ALPS, SJS, Fas, FasL, and apoptosis. STUDY SELECTION: Case reports of ALPS and SJS were selected as examples of Fas- and FasL-mediated diseases. In addition, we selected articles that examined the pathophysiology of apoptosis in the context of Fas-FasL interaction. RESULTS: Failure to initiate apoptosis of abnormal T lymphocytes occurs in such diseases as ALPS, leading to the accumulation of double negative T cells with an increase in autoimmunity. In contrast to apoptotic failure, SJS is associated with a pathological increase in programmed keratinocyte cell death. CONCLUSION: The consequences of dysregulated Fas- and FasL-mediated apoptosis leads to self-reactivity, malignant transformation, and immune dysfunction. An understanding of underlying mechanisms and qualitative assessment of Fas and FasL may have clinical benefits when control of these homeostatic mechanisms is in question.
File Format	HTM / HTML
ISSN	10811206
Issue Number	4
Volume Number	104
e-ISSN	15344436
Journal	Annals of Allergy, Asthma & Immunology
Language	English
Publisher	Elsevier (on behalf of the American College of Allergy, Asthma and Immunology)
Publisher Date	2010-04-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Antigens, Cd95 Metabolism Autoimmune Lymphoproliferative Syndrome Physiopathology Fas Ligand Protein Stevens-johnson Syndrome Adult Genetics Apoptosis Physiology Drug Therapy Immunology Pathology Female Humans Infant Case Reports Journal Article Meta-analysis Review
Content Type	Text
Resource Type	Case study Article
Subject	Pulmonary and Respiratory Medicine Immunology and Allergy Immunology

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