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An FMRI study of frontostriatal circuits during the inhibition of eye blinking in persons with Tourette syndrome.

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An FMRI study of frontostriatal circuits during the inhibition of eye blinking in persons with Tourette syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mazzone, Luigi Yu, Shan Blair, Clancy Gunter, Benjamin C. Wang, Zhishun Marsh, Rachel Peterson, Bradley S.
Description	Country affiliation: United States Author Affiliation: Mazzone L ( Department of Psychiatry, Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.)
Abstract	OBJECTIVE: The authors sought to study activity in neural circuits that subserve the inhibition of a semi-involuntary motor behavior, eye blinking, in children and adults with Tourette syndrome and in healthy comparison subjects. METHOD: Functional magnetic resonance imaging was used to scan 120 participants (51 with Tourette syndrome and 69 comparison subjects) as they either blinked normally or successfully inhibited eye blinking. The authors compared the blood-oxygen-level dependent signal during these two conditions across the Tourette and comparison groups. RESULTS: Relative to comparison subjects, patients with Tourette syndrome activated more strongly the frontal cortex and striatum during eye blink inhibition. Activation increased more with age in the dorsolateral and inferolateral prefrontal cortex and caudate nucleus in the Tourette group relative to comparison subjects. In addition, the Tourette group more strongly activated the middle frontal gyrus, dorsal anterior cingulate, and temporal cortices. The severity of tic symptoms in the Tourette group correlated inversely with activation in the putamen and inferolateral prefrontal cortex. CONCLUSIONS: Frontostriatal activity is increased in persons with Tourette syndrome during the inhibition of eye blinks. Activation of frontostriatal circuits in this population may help to maintain regulatory control over semi-involuntary behaviors, whether these are tics or eye blinks.
File Format	HTM / HTML
ISSN	0002953X
e-ISSN	15357228
DOI	10.1176/appi.ajp.2009.08121831
Journal	American Journal of Psychiatry
Issue Number	3
Volume Number	167
Language	English
Publisher	American Psychiatric Association
Publisher Date	2010-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Psychiatry Blinking Physiology Corpus Striatum Physiopathology Frontal Lobe Image Interpretation, Computer-assisted Inhibition (psychology) Magnetic Resonance Imaging Nerve Net Tourette Syndrome Adolescent Caudate Nucleus Dominance, Cerebral Gyrus Cinguli Neuronal Plasticity Prefrontal Cortex Putamen Temporal Lobe Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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