NDLI: D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis.

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D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Jian-Ping Lencz, Todd Malhotra, Anil K.
Description	Country affiliation: United States Author Affiliation: Zhang JP ( Division of Psychiatry Research, Department of Psychiatry, The Zucker Hillside Hospital, 75-59 263rd St., Glen Oaks, NY 11004, USA. jzhang1@nshs.edu)
Abstract	OBJECTIVE: Several lines of evidence suggest that antipsychotic drug efficacy is mediated by dopamine type 2 (D(2)) receptor blockade. Therefore, it seems plausible that variation in the DRD(2) gene is associated with clinical response to antipsychotic drug treatment. The authors conducted the first meta-analysis to examine the relationship between DRD2 polymorphisms and antipsychotic drug response. METHOD: A MEDLINE search of articles available up to December 31, 2008, yielded 18 prospective studies examining DRD2 gene variation and antipsychotic response in schizophrenia patients; of which, 10 independent studies met criteria for inclusion. Clinical response to antipsychotic treatment was defined as a 50% reduction of either the Brief Psychiatric Rating Scale total score or Positive and Negative Syndrome Scale total score at approximately 8 weeks of follow-up evaluation. Odds ratio was the primary effect-size measure and computed for each polymorphism in each study. Sufficient data were available for two DRD2 polymorphisms: -141C Ins/Del and Taq1A. RESULTS: Six studies reported results for the -141C Ins/Del polymorphism (total sample size: N=687). The Del allele carrier was significantly associated with poorer antipsychotic drug response relative to the Ins/Ins genotype. Eight studies assessed the Taq1A polymorphism and antipsychotic response (total sample size: N=748). There was no significant difference in the response rate among A1 allele carriers relative to individuals with the A2/A2 genotype or A2 allele carriers relative to individuals with the A1/A1 genotype. CONCLUSIONS: The DRD2 genetic variation is associated with clinical response to antipsychotic drug treatment. These data may provide proof-of-principle for pharmacogenetic studies in schizophrenia.
File Format	HTM / HTML
ISSN	0002953X
e-ISSN	15357228
DOI	10.1176/appi.ajp.2009.09040598
Journal	American Journal of Psychiatry
Issue Number	7
Volume Number	167
Language	English
Publisher	American Psychiatric Association
Publisher Date	2010-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Psychiatry Antipsychotic Agents Therapeutic Use Receptors, Dopamine D2 Genetics Schizophrenia Alleles Genotype Polymorphism, Genetic Polymorphism, Single Nucleotide Psychiatric Status Rating Scales Drug Therapy Meta-analysis Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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