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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, Junghee Altshuler, Lori Glahn, David C. Miklowitz, David J. Ochsner, Kevin Green, Michael F. |
| Description | Country affiliation: United States Author Affiliation: Lee J ( Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, USA. jungheelee@ucla.edu) |
| Abstract | OBJECTIVE: This study aimed to determine the relative extent of impairment in social and nonsocial cognitive domains in patients with bipolar disorder compared with schizophrenia patients and healthy comparison subjects. METHODS: Sixty-eight clinically stable outpatients with bipolar disorder, 38 clinically stable outpatients with schizophrenia, and 36 healthy comparison subjects completed a range of social (facial affect perception, emotional regulation, empathic accuracy, mental state attribution, and self-referential memory) and nonsocial (speed of processing, attention/vigilance, working memory, verbal memory, visual memory, and reasoning/problem solving) cognitive tasks. RESULTS: For each social cognitive task, patients with bipolar disorder did not differ significantly from comparison subjects, and both groups performed better than schizophrenia patients. Within the bipolar group, clinical features and medication status were not related to social cognitive performance. Bipolar patients showed performance patterns across tasks (i.e., profiles) that were similar to those of comparison subjects on both social and nonsocial cognitive domains, whereas both groups differed from schizophrenia patients for both domains. Regarding relative impairment across the two cognitive domains, results revealed a significant group-by-domain interaction in which bipolar patients showed less impaired social than nonsocial cognition, while schizophrenia patients showed the opposite pattern. CONCLUSIONS: Bipolar patients showed less impairment on social relative to nonsocial cognitive performance, whereas schizophrenia patients showed more impairment on social relative to nonsocial cognitive performance. These results suggest that these two cognitive domains play different roles in bipolar disorder compared with in schizophrenia. |
| File Format | HTM / HTML |
| ISSN | 0002953X |
| e-ISSN | 15357228 |
| DOI | 10.1176/appi.ajp.2012.12040490 |
| Journal | American Journal of Psychiatry |
| Issue Number | 3 |
| Volume Number | 170 |
| Language | English |
| Publisher | American Psychiatric Association |
| Publisher Date | 2013-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Psychiatry Bipolar Disorder Diagnosis Cognition Disorders Schizophrenia Social Adjustment Social Behavior Disorders Attention Psychology Emotional Intelligence Emotions Empathy Facial Expression Interpersonal Relations Memory Disorders Memory, Episodic Neuropsychological Tests Personal Construct Theory Problem Solving Recognition (psychology) Schizophrenic Psychology Social Perception Theory Of Mind Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health |
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