NDLI: FDG-PET-CT for staging of high-risk breast cancer patients reduces the number of further examinations: A pilot study.

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FDG-PET-CT for staging of high-risk breast cancer patients reduces the number of further examinations: A pilot study.

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FDG-PET-CT for staging of high-risk breast cancer patients reduces the number of further examinations: A pilot study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jager, Jos J. Keymeulen, Kristien Beets-Tan, Regina G. H. Hupperets, Pierre Van Kroonenburgh, Marinus Houben, Ruud de Ruysscher, Dirk Lambin, Philippe Boersma, Liesbeth J.
Description	Country affiliation: Netherlands Author Affiliation: Jager JJ ( MAASTRO Clinic, Department of Radiation Oncology, 6202 NA Maastricht, The Netherlands. jos.jager@maastro.nl)
Abstract	AIM: To determine the additional value of FDG-PET-CT as compared to conventional staging (CS) in high-risk breast cancer patients. PATIENTS AND METHODS: Thirty-one high-risk breast cancer patients, 14 of whom had recurrent breast cancer, were included in this study, which took place between June 2005 and March 2008. None of the patients had clinical signs of distant metastases. FDG-PET-CT scanning was added to CS, which consisted of a chest x-ray, liver ultrasonography or CT, and bone scintigraphy. Median follow-up was 17 months (6-41 months). FDG-PET-CT was considered to have additional value to CS if it led to a change in treatment plan or if it made additional examinations to confirm or deny findings on CS unnecessary. RESULTS: FDG-PET-CT was considered to have additional value to CS in 13 patients (42% [95% CI: 23-61]). In five patients (16% [95% CI: 1-31]), FDG-PET-CT led to a change in treatment plan by identifying nodal metastases in the internal mammary chain (IMC; N = 3) or in the mediastinum (N = 2). In nine patients (29% [95% CI: 11-47]), FDG-PET-CT would have prevented the need for additional examinations; in seven of these nine patients, distant metastases were suggested in bone or liver on CS, but these did not show FDG uptake. CONCLUSIONS: FDG-PET-CT was found to have additional value to CS in 42% of the patients. To optimize cost-effectiveness, the main challenge now is to improve the selection of patients in whom FDG-PET-CT has additional value to CS.
File Format	HTM / HTML
ISSN	0284186X
e-ISSN	1651226X
Journal	Acta Oncologica
Issue Number	2
Volume Number	49
Language	English
Publisher	Taylor and Francis
Publisher Date	2010-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Oncology Breast Neoplasms Diagnosis Neoplasm Staging Positron-emission Tomography Tomography, X-ray Computed Fluorodeoxyglucose F18 Pilot Projects Radiopharmaceuticals Clinical Trial
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Hematology Oncology

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