NDLI: Long-term effects on the incidence of second primary cancers in a randomized trial of two and five years of adjuvant tamoxifen.

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Long-term effects on the incidence of second primary cancers in a randomized trial of two and five years of adjuvant tamoxifen.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rosell, Johan Nordenskjöld, Bo Bengtsson, Nils-Olof Fornander, Tommy Hatschek, Thomas Lindman, Henrik Malmström, Per-Olof Wallgren, Arne Stål, Olle Carstensen, John
Description	Country affiliation: Sweden Author Affiliation: Rosell J ( a Regional Cancer Center South East Sweden , Linköping , Sweden.); Nordenskjöld B ( b Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences , Linköping University , Linköping , Sweden.); Bengtsson NO ( b Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences , Linköping University , Linköping , Sweden.); Fornander T ( c Department of Oncology , Umeå University Hospital , Umeå , Sweden.); Hatschek T ( d Department of Oncology , Karolinska University Hospital , Stockholm , Sweden.); Lindman H ( d Department of Oncology , Karolinska University Hospital , Stockholm , Sweden.); Malmström PO ( e Department of Oncology , Uppsala University Hospital , Uppsala , Sweden.); Wallgren A ( f Skånes Department of Oncology , Skåne University Hospital , Lund , Sweden.); Stål O ( g Department of Oncology , Sahlgrenska University Hospital , Göteborg , Sweden.); Carstensen J ( b Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences , Linköping University , Linköping , Sweden.)
Abstract	BACKGROUND: Tamoxifen is a well established treatment for breast cancer, but its long-term effects on the incidence of secondary cancers are not fully evaluated. MATERIAL AND METHODS: We have studied 4128 postmenopausal patients with early stage breast cancer who were alive and free of breast cancer recurrence after two years of tamoxifen, and who were randomized to receive totally two or five years of therapy. RESULTS: Compared to patients randomized to two years of tamoxifen the incidence of contralateral breast cancer [hazard ratio (HR) 0.73; 95% CI 0.56-0.96] and of lung cancer (HR 0.45; 95% CI 0.27-0.77), especially squamous cell and small cell lung cancer, were reduced in the five-year group, and similar results were seen when restricting the analysis to the 10-year period after treatment stopped. An increased incidence of endometrial cancer was observed in the five-year group, but the excess risk decreased over time. CONCLUSION: Further studies of the effects of tamoxifen on the risk of different histological types of lung cancer are needed.
File Format	HTM / HTML
ISSN	0284186X
e-ISSN	1651226X
Journal	Acta Oncologica
Language	English
Publisher	Taylor and Francis
Publisher Date	2017-01-12
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Hematology Oncology

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