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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | D'Arcy, Allan Chaillet, Maxime Schiering, Nikolaus Villard, Frederic Lim, Siew Pheng Lefeuvre, Peggy Erbel, Paul |
| Description | Country affiliation: Switzerland Author Affiliation: D'Arcy A ( Novartis Institutes of Biomedical Research, Protease Platform, Klybeckstrasse 144, CH 4002 Basel, Switzerland. allan.darcy@novartis.com) |
| Abstract | Both dengue and West Nile virus infections are an increasing risk to humans, not only in tropical and subtropical areas, but also in North America and parts of Europe. These viral infections are generally transmitted by mosquitoes, but may also be tick-borne. Infection usually results in mild flu-like symptoms, but can also cause encephalitis and fatalities. Approximately 2799 severe West Nile virus cases were reported this year in the United States, resulting in 102 fatalities. With this alarming increase in the number of West Nile virus infections in western countries and the fact that dengue virus already affects millions of people per year in tropical and subtropical climates, there is a real need for effective medicines. A possible therapeutic target to combat these viruses is the protease, which is essential for virus replication. In order to provide structural information to help to guide a lead identification and optimization program, crystallizations of the NS2B-NS3 protease complexes from both dengue and West Nile viruses have been initiated. Crystals that diffract to high resolution, suitable for three-dimensional structure determinations, have been obtained. |
| File Format | HTM / HTML |
| ISSN | 2053230X |
| e-ISSN | 17443091 |
| Journal | Acta Crystallographica Section F Structural Biology and Crystallization Communications |
| Issue Number | Pt 2 |
| Volume Number | 62 |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2006-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Crystallography Discipline Biophysics Discipline Molecular Biology Discipline Biochemistry Cysteine Endopeptidases Isolation & Purification Dengue Virus Enzymology Serine Endopeptidases Viral Nonstructural Proteins West Nile Virus Crystallization Crystallography, X-ray Chemistry Multiprotein Complexes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Structural Biology Medicine Biochemistry Biophysics Condensed Matter Physics |
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