NDLI: The JCSG high-throughput structural biology pipeline.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Elsliger, Marc André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wooley, John Wüthrich, Kurt Wilson, Ian A.
Description	Country affiliation: United States Author Affiliation: Elsliger MA ( Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA.)
Abstract	The Joint Center for Structural Genomics high-throughput structural biology pipeline has delivered more than 1000 structures to the community over the past ten years. The JCSG has made a significant contribution to the overall goal of the NIH Protein Structure Initiative (PSI) of expanding structural coverage of the protein universe, as well as making substantial inroads into structural coverage of an entire organism. Targets are processed through an extensive combination of bioinformatics and biophysical analyses to efficiently characterize and optimize each target prior to selection for structure determination. The pipeline uses parallel processing methods at almost every step in the process and can adapt to a wide range of protein targets from bacterial to human. The construction, expansion and optimization of the JCSG gene-to-structure pipeline over the years have resulted in many technological and methodological advances and developments. The vast number of targets and the enormous amounts of associated data processed through the multiple stages of the experimental pipeline required the development of variety of valuable resources that, wherever feasible, have been converted to free-access web-based tools and applications.
File Format	HTM / HTML
ISSN	2053230X
e-ISSN	17443091
DOI	10.1107/S1744309110038212
Journal	Acta Crystallographica Section F Structural Biology and Crystallization Communications
Issue Number	Pt 10
Volume Number	66
Language	English
Publisher	Wiley
Publisher Date	2010-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Crystallography Discipline Biophysics Discipline Molecular Biology Discipline Biochemistry Databases, Genetic Genomics Protein Conformation Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Genetics Structural Biology Medicine Biochemistry Biophysics Condensed Matter Physics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

TOPSAN: use of a collaborative environment for annotating, analyzing and disseminating data on JCSG and PSI structures.

Ligands in PSI structures.

NMR in a crystallography-based high-throughput protein structure-determination environment.

The JCSG high-throughput structural biology pipeline

Preliminary structural studies on the leucine-zipper homology region of the human protein Bap31.

DUFs: families in search of function.

Crystallization Optimum Solubility Screening: using crystallization results to identify the optimal buffer for protein crystal formation.

Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus.

Publishing structural genomics results: the JCSG Special Issue.

The JCSG high-throughput structural biology pipeline.

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TOPSAN: use of a collaborative environment for annotating, analyzing and disseminating data on JCSG and PSI structures.

Ligands in PSI structures.

NMR in a crystallography-based high-throughput protein structure-determination environment.

The JCSG high-throughput structural biology pipeline

Preliminary structural studies on the leucine-zipper homology region of the human protein Bap31.

DUFs: families in search of function.

Crystallization Optimum Solubility Screening: using crystallization results to identify the optimal buffer for protein crystal formation.

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