NDLI: Adding sufentanil to levobupivacaine or ropivacaine intrathecal anaesthesia affects the minimum local anaesthetic dose required.

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Adding sufentanil to levobupivacaine or ropivacaine intrathecal anaesthesia affects the minimum local anaesthetic dose required.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Parpaglioni, R. Baldassini, B. Barbati, G. Celleno, D.
Description	Country affiliation: Italy Author Affiliation: Parpaglioni R ( Department of Anaesthesia and Intensive Care, Fatebenefratelli General Hospital, 00186 Rome, Italy. rparpaglioni@email.it)
Abstract	BACKGROUND: We carried out this prospective, randomized, double-blind study in order to evaluate whether the intrathecal addition of sufentanil 3.3 mcg affects both the minimum local anaesthetic dose (MLAD) of spinal levobupivacaine and ropivacaine for a caesarean section and enhances the spinal block characteristics. METHODS: One hundred and eighty women were randomly allocated into four groups: levobupivacaine (Group L), levobupivacaine plus sufentanil (Group L+S), ropivacaine (Group R) and ropivacaine plus sufentanil (Group R+S). Each received 3 ml of the study solution intrathecally as part of a combined spinal/epidural technique. The initial dose was 12 mg for Groups L and L+S, and 15 mg for Groups R and R+S. The test solution was required to achieve a visual analogue pain score (VAPS) of 30 mm or less to be considered effective at skin incision, uterine incision, birth, peritoneal closure and at the conclusion of surgery. Effective or ineffective responses determined a 0.5 mg decrease or increase of the same drug, respectively, for the next patient in the same group, using an up-down sequential allocation. RESULTS: Using the Dixon and Massey formula, the MLAD was 10.65 mg [confidence interval (CI) 95%: 10.14-11.56] in Group L, 4.73 mg (CI 95%: 4.39-5.07) in Group L+S, 14.12 mg (CI 95%: 13.50-14.60) in Group R and 6.44 mg (CI 95%: 5.86-7.02) in Group R+S. CONCLUSIONS: The addition of sufentanil reduced the MLAD of both the local anaesthetics. It did not affect their potency ratio significantly and resulted in enhanced spinal anaesthesia.
File Format	HTM / HTML
ISSN	00015172
Issue Number	9
Volume Number	53
e-ISSN	00015172
Journal	Acta Anaesthesiologica Scandinavica
Language	English
Publisher	Wiley
Publisher Date	2009-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Anesthesiology Amides Administration & Dosage Anesthesia, Obstetrical Anesthesia, Spinal Anesthetics, Intravenous Anesthetics, Local Sufentanil Adult Anesthesia Recovery Period Bupivacaine Analogs & Derivatives Cesarean Section Double-blind Method Female Humans Logistic Models Monitoring, Intraoperative Pain Measurement Postoperative Nausea And Vomiting Epidemiology Pregnancy Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

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Adding sufentanil to levobupivacaine or ropivacaine intrathecal anaesthesia affects the minimum local anaesthetic dose required.