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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cheung, C. W. Qiu, Q. Liu, J. Chu, K. M. Irwin, M. G. |
| Description | Country affiliation: Hong Kong Author Affiliation: Cheung CW ( Department of Anaesthesiology, The University of Hong Kong, Hong Kong.) |
| Abstract | BACKGROUND: Sedation using intranasal dexmedetomidine is a convenient and well-tolerated technique. This study evaluated the sedative efficacy of intranasal dexmedetomidine in combination with patient-controlled sedation (PCS) for upper gastrointestinal endoscopy. METHODS: In this double-blind, randomised, controlled trial, 50 patients received either intranasal dexmedetomidine 1.5 µg/kg (dexmedetomidine group) or intranasal saline (placebo group) 1 h before the procedure. PCS with propofol and alfentanil was provided for rescue sedation. Additional sedative consumption, perioperative sedation scores using Observer's Assessment of Alertness/Sedation (OAA/S) scale, recovery, vital signs, adverse events and patient satisfaction were assessed. RESULTS: Total consumption of PCS propofol and alfentanil was significantly less in the dexmedetomidine than placebo group with a mean difference of -13.8 mg propofol (95% confidence interval -27.3 to -0.3) and -34.5 µg alfentanil (95% confidence interval -68.2 to -0.7) at the completion of the procedure (P = 0.044). Weighted areas under the curve (AUCw ) of OAA/S scores were significantly lower in the dexmedetomidine group before, during and after procedures (P < 0.001, P = 0.024 and P = 0.041 respectively). AUCw of heart rate and systolic blood pressure were also significantly lower during the procedure (P = 0.007 and P = 0.022 respectively) with dexmedetomidine. There was no difference in recovery, side effects or satisfaction. CONCLUSION: Intranasal dexmedetomidine with PCS propofol and alfentanil confers deeper perioperative clinical sedation with significantly less use of additional sedatives during upper gastrointestinal endoscopy. |
| File Format | HTM / HTML |
| ISSN | 00015172 |
| Issue Number | 2 |
| Volume Number | 59 |
| e-ISSN | 00015172 |
| Journal | Acta Anaesthesiologica Scandinavica |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Anesthesiology Analgesia, Patient-controlled Methods Dexmedetomidine Therapeutic Use Endoscopy, Gastrointestinal Hypnotics And Sedatives Administration, Intranasal Adult Alfentanil Administration & Dosage Analgesics, Opioid Conscious Sedation Double-blind Method Female Humans Male Patient Satisfaction Propofol Sodium Chloride Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine |
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