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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kawano, Fuminori Takeno, Yoshiaki Nakai, Naoya Higo, Yoko Terada, Masahiro Ohira, Takashi Nonaka, Ikuya Ohira, Yoshinobu |
| Description | Country affiliation: Japan Author Affiliation: Kawano F ( Graduate School of Medicine, Osaka University, Osaka, Japan.) |
| Abstract | Effects of gravitational loading or unloading on the growth-associated increase in the cross-sectional area and length of fibers, as well as the total fiber number, in soleus muscle were studied in rats. Furthermore, the roles of satellite cells and myonuclei in growth of these properties were also investigated. The hindlimb unloading by tail suspension was performed in newborn rats from postnatal day 4 to month 3 with or without 3-mo reloading. The morphological properties were measured in whole muscle and/or single fibers sampled from tendon to tendon. Growth-associated increases of soleus weight and fiber cross-sectional area in the unloaded group were approximately 68% and 69% less than the age-matched controls. However, the increases of number and length of fibers were not influenced by unloading. Growth-related increases of the number of quiescent satellite cells and myonuclei were inhibited by unloading. And the growth-related decrease of mitotically active satellite cells, seen even in controls (20%, P > 0.05), was also stimulated (80%). The increase of myonuclei during 3-mo unloading was only 40 times vs. 92 times in controls. Inhibited increase of myonuclear number was not related to apoptosis. The size of myonuclear domain in the unloaded group was less and that of single nuclei, which was decreased by growth, was larger than controls. However, all of these parameters, inhibited by unloading, were increased toward the control levels generally by reloading. It is suggested that the satellite cell-related stimulation in response to gravitational loading plays an essential role in the cross-sectional growth of soleus muscle fibers. |
| File Format | HTM / HTML |
| ISSN | 03636143 |
| e-ISSN | 15221563 |
| Journal | American Journal of Physiology - Cell Physiology |
| Issue Number | 2 |
| Volume Number | 295 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2008-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cell Biology Cell Proliferation Muscle Fibers, Skeletal Physiology Muscle, Skeletal Growth & Development Satellite Cells, Skeletal Muscle Animals Animals, Newborn Apoptosis Body Weight Bromodeoxyuridine Metabolism Cadherins Cell Nucleus Chemistry Gravitation Models, Biological Cytology Anatomy & Histology Rats, Wistar Weight-bearing Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology |
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