NDLI: The monomeric G proteins AGS1 and Rhes selectively influence Galphai-dependent signaling to modulate N-type (CaV2.2) calcium channels.

Please wait, while we are loading the content...

Year: 2017 Volume: 312

Year: 2016 Volume: 311

Year: 2016 Volume: 310

Year: 2015 Volume: 309

Year: 2015 Volume: 308

Year: 2014 Volume: 307

Year: 2014 Volume: 306

Year: 2013 Volume: 305

Year: 2013 Volume: 304

Year: 2012 Volume: 303

Year: 2012 Volume: 302

Year: 2011 Volume: 301

Year: 2011 Volume: 300

Year: 2010 Volume: 299

Year: 2010 Volume: 298

Year: 2009 Volume: 297

Year: 2009 Volume: 296

Year: 2008 Volume: 295

Year: 2008 Volume: 295 Issue: 6

Year: 2008 Volume: 295 Issue: 5

Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways.

Electron probe X-ray microanalysis of intact pathway for human aqueous humor outflow

Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells.

Early mechanical dysfunction of the diaphragm in the muscular dystrophy with myositis (Ttnmdm) model.

How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and $I_{CRAC}$ activation?

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.

Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids.

Ankyrin facilitates intracellular trafficking of alpha1-Na+-K+-ATPase in polarized cells.

MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells.

Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions.

MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides.

Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma alter tight junction structure and function in the rat parotid gland Par-C10 cell line.

Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA.

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1.

Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells.

Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells.

Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing.

Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton.

Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.

Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells.

In vitro neovasculogenic potential of resident adipose tissue precursors.

Oxidant-induced inhibition of the plasma membrane $Ca^{2+}-ATPase$ in pancreatic acinar cells: role of the mitochondria

Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells

Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork.

Renal proximal tubules from old Fischer 344 rats grow into epithelial cells in cultures and exhibit increased oxidative stress and reduced D1 receptor function.

Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, $Ca^{2+}$ signals, and vasoconstriction in cerebral arteries

Substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes.

Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling

Activation of $Na^{+}/H^{+}$ and $K^{+}/H^{+}$ exchange by calyculin A in Amphiuma tridactylum red blood cells: implications for the control of volume-induced ion flux activity

PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR.

Stimulation of β3-adrenoceptors relaxes rat urinary bladder smooth muscle via activation of the large-conductance $Ca^{2+}-activated$ $K^{+}$ channels

Impact of overexpression of metallothionein-1 on cell cycle progression and zinc toxicity

The monomeric G proteins AGS1 and Rhes selectively influence Galphai-dependent signaling to modulate N-type (CaV2.2) calcium channels.

Anisotropic diffusion of fluorescently labeled ATP in rat cardiomyocytes determined by raster image correlation spectroscopy.

The use of BeWo cells as an in vitro model for placental iron transport.

Regulation of cell proliferation by intermediate-conductance Ca2+-activated potassium and volume-sensitive chloride channels in mouse mesenchymal stem cells.

Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix.

Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells.

Human neutrophil surface protrusion under a point load: location independence and viscoelasticity.

Measuring ion transport activities in Xenopus oocytes using the ion-trap technique.

Inhibition of $Na^{+}/H^{+}$ exchanger enhances low pH-induced L-selectin shedding and $β_{2}-integrin$ surface expression in human neutrophils

Year: 2008 Volume: 295 Issue: 4

Year: 2008 Volume: 295 Issue: 3

Year: 2008 Volume: 295 Issue: 2

Year: 2008 Volume: 295 Issue: 1

Year: 2008 Volume: 294

Year: 2007 Volume: 293

Year: 2007 Volume: 292

Year: 2006 Volume: 291

Year: 2006 Volume: 290

Year: 2005 Volume: 289

Year: 2005 Volume: 288

Year: 2004 Volume: 286

Year: 2003 Volume: 284

Year: 2002 Volume: 283

Year: 2002 Volume: 282

Year: 2001 Volume: 281

Year: 2001 Volume: 280

Year: 2000 Volume: 279

The monomeric G proteins AGS1 and Rhes selectively influence Galphai-dependent signaling to modulate N-type (CaV2.2) calcium channels.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Thapliyal, Ashish Bannister, Roger A. Hanks, Christopher Adams, Brett A.
Description	Country affiliation: United States Author Affiliation: Thapliyal A ( Dept. of Biology, Utah State Univ., 5305 Old Main Hill, Logan, UT 84322, USA.)
Abstract	Activator of G protein Signaling 1 (AGS1) and Ras homologue enriched in striatum (Rhes) define a new group of Ras-like monomeric G proteins whose signaling properties and physiological roles are just beginning to be understood. Previous results suggest that AGS1 and Rhes exhibit distinct preferences for heterotrimeric G proteins, with AGS1 selectively influencing Galphai and Rhes selectively influencing Galphas. Here, we demonstrate that AGS1 and Rhes trigger nearly identical modulation of N-type Ca(2+) channels (Ca(V)2.2) by selectively altering Galphai-dependent signaling. Whole-cell currents were recorded from HEK293 cells expressing Ca(V)2.2 and Galphai- or Galphas-coupled receptors. AGS1 and Rhes reduced basal current densities and triggered tonic voltage-dependent (VD) inhibition of Ca(V)2.2. Additionally, each protein attenuated agonist-initiated channel inhibition through Galphai-coupled receptors without reducing channel inhibition through a Galphas-coupled receptor. The above effects of AGS1 and Rhes were blocked by pertussis toxin (PTX) or by expression of a Gbetagamma-sequestering peptide (masGRK3ct). Transfection with HRas, KRas2, Rap1A-G12V, Rap2B, Rheb2, or Gem failed to duplicate the effects of AGS1 and Rhes on Ca(V)2.2. Our data provide the first demonstration that AGS1 and Rhes exhibit similar if not identical signaling properties since both trigger tonic Gbetagamma signaling and both attenuate receptor-initiated signaling by the Gbetagamma subunits of PTX-sensitive G proteins. These results are consistent with the possibility that AGS1 and Rhes modulate Ca(2+) influx through Ca(V)2.2 channels under more physiological conditions and thereby influence Ca(2+)-dependent events such as neurosecretion.
File Format	HTM / HTML
ISSN	03636143
e-ISSN	15221563
Journal	American Journal of Physiology - Cell Physiology
Issue Number	5
Volume Number	295
Language	English
Publisher	American Physiological Society
Publisher Date	2008-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cell Biology Calcium Channels, N-type Metabolism Gtp-binding Protein Alpha Subunits, Gi-go Gtp-binding Proteins Proteins Signal Transduction Animals Drug Effects Genetics Carbachol Pharmacology Cell Line Cholinergic Agonists Exodeoxyribonucleases Gtp-binding Protein Beta Subunits Gtp-binding Protein Gamma Subunits Membrane Potentials Pertussis Toxin Phosphoproteins Rabbits Receptor, Muscarinic M2 Agonists Receptors, Adrenergic, Beta-2 Transfection Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in