NDLI: Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-κB recruitment to cytokine gene promoters

Please wait, while we are loading the content...

Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-κB recruitment to cytokine gene promoters

TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB.

Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels.

Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase.

Transporters beyond transport. Focus on 'Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels'.

Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway

FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70.

Anionic leak currents through the Na+/monocarboxylate cotransporter SMCT1.

Epidermal growth factor increases lysophosphatidic acid production in human ovarian cancer cells: roles for phospholipase D2 and receptor transactivation.

Dysregulation of very long chain acyl-CoA dehydrogenase coupled with lipid peroxidation.

Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts

Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle

Revisiting the parietal cell.

Voltage-dependent facilitation of Cx46 hemichannels.

Year: 2009 Volume: 297

Year: 2009 Volume: 296

Year: 2008 Volume: 295

Year: 2008 Volume: 294

Year: 2007 Volume: 293

Year: 2007 Volume: 292

Year: 2006 Volume: 291

Year: 2006 Volume: 290

Year: 2005 Volume: 289

Year: 2005 Volume: 288

Year: 2004 Volume: 286

Year: 2003 Volume: 284

Year: 2002 Volume: 283

Year: 2002 Volume: 282

Year: 2001 Volume: 281

Year: 2001 Volume: 280

Year: 2000 Volume: 279

Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-κB recruitment to cytokine gene promoters

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cooper, Zachary A. Ghosh, Arundhati Gupta, Aditi Maity, Tapan Benjamin, Ivor J. Vogel, Stefanie N. Hasday, Jeffrey D. Singh, Ishwar S.
Description	Country affiliation: United States Author Affiliation: Cooper ZA ( Univ. of Maryland School of Medicine, Health Science Facility-II, Rm. S311, 20 Penn St., Baltimore, MD 21201,USA.)
Abstract	We previously showed that exposure to febrile-range temperatures (FRT, 39.5-40 degrees C) reduces LPS-induced TNF-alpha expression, in part through the direct interaction of heat shock factor-1 (HSF1) with the TNF-alpha gene promoter. However, it is not known whether exposure to FRT also modifies more proximal LPS-induced signaling events. Using HSF1-null mice, we confirmed that HSF1 is required for FRT-induced repression of TNF-alpha in vitro by LPS-stimulated bone marrow-derived macrophages and in vivo in mice challenged intratracheally with LPS. Exposing LPS-stimulated RAW 264.7 mouse macrophages to FRT reduced TNF-alpha expression while increasing IL-1beta expression despite the two genes sharing a common myeloid differentiation protein-88 (MyD88)-dependent pathway. Global activation of the three LPS-induced signaling intermediates that lead to cytokine gene expression, ERK and p38 MAPKs and NF-kappaB, was not affected by exposing RAW 264.7 cells to FRT as assessed by ERK and p38 phosphorylation and NF-kappaB in vitro DNA-binding activity and activation of a NF-kappaB-dependent synthetic promoter. However, chromatin immunoprecipitation (ChIP) analysis demonstrated that exposure to FRT reduced LPS-induced recruitment of NF-kappaB p65 to the TNF-alpha promoter while simultaneously increasing its recruitment to the IL-1beta promoter. These data suggest that FRT exerts its effects on cytokine gene expression in a gene-specific manner through distal effects on promoter activation rather than proximal receptor activation and signal transduction.
File Format	HTM / HTML
ISSN	03636143
e-ISSN	15221563
DOI	10.1152/ajpcell.00346.2009
Journal	American Journal of Physiology - Cell Physiology
Issue Number	1
Volume Number	298
Language	English
Publisher	American Physiological Society
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cell Biology Cytokines Genetics Fever Physiopathology Gene Expression Regulation Physiology Lipopolysaccharides Pharmacology Macrophages Nf-kappa B Promoter Regions, Genetic Tumor Necrosis Factor-alpha Animals Chromatin Crosses, Genetic Dna-binding Proteins Deficiency Drug Effects Interleukin-1beta Mice Mice, Knockout Polymerase Chain Reaction Isolation & Purification Temperature Transcription Factors Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-κB recruitment to cytokine gene promoters

Liver Kinase B1 Suppresses Lipopolysaccharide-induced Nuclear Factor κB (NF-κB) Activation in Macrophages

Febrile range temperature represses TNF-α gene expression in LPS-stimulated macrophages by selectively blocking recruitment of Sp1 to the TNF-α promoter

NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages.

Transient membrane recruitment of IRAK-1 in response to LPS and IL-1beta requires TNF R1.

Acute Hypoxia Decreases E. coli LPS-Induced Cytokine Production and NF-κB Activation in Alveolar Macrophages

Inhibition of Neddylation Represses Lipopolysaccharide-induced Proinflammatory Cytokine Production in Macrophage Cells

Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.

Docosahexaenoic acid differentially affects TNF and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages.

Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-κB recruitment to cytokine gene promoters

Similar Documents

Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-κB recruitment to cytokine gene promoters

Liver Kinase B1 Suppresses Lipopolysaccharide-induced Nuclear Factor κB (NF-κB) Activation in Macrophages

Febrile range temperature represses TNF-α gene expression in LPS-stimulated macrophages by selectively blocking recruitment of Sp1 to the TNF-α promoter

NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages.

Transient membrane recruitment of IRAK-1 in response to LPS and IL-1beta requires TNF R1.

Acute Hypoxia Decreases E. coli LPS-Induced Cytokine Production and NF-κB Activation in Alveolar Macrophages

Inhibition of Neddylation Represses Lipopolysaccharide-induced Proinflammatory Cytokine Production in Macrophage Cells

Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.

Docosahexaenoic acid differentially affects TNF and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages.

Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-κB recruitment to cytokine gene promoters